Results 51 to 60 of about 476,229 (267)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Identification of important candidate genes in minks with self-biting behaviour using weighted gene coexpression network analysis

BMC Genomics
Background Mink self-biting behaviour causes skin damage, reducing fur quality and restricting the development of the mink farming industry. The aim of this study was to investigate the genetic mechanisms underlying self-biting behaviour in minks from a ...
Jie Liu, Yuan Xu, Xue Han, Chao Li, Wei Xu, Xue Bai, Yuxiang Wang, Zhiheng Du   +7 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Optimization of Genomic Breeding Value Estimation Model for Abdominal Fat Traits Based on Machine Learning

Animals
Abdominal fat is a key indicator of chicken meat quality. Excessive deposition not only reduces meat quality but also decreases feed conversion efficiency, making the breeding of low-abdominal-fat strains economically important.
Hengcong Chen, Dachang Dou, Min Lu, Xintong Liu, Cheng Chang, Fuyang Zhang, Shengwei Yang, Zhiping Cao, Peng Luan, Yumao Li, Hui Zhang   +10 more
doaj   +1 more source

Coon Chicken Inn Advertisement

, 1925
Color photograph of Advertisement From Coon Chicken Inn featuring stereotypical African American ...
Coon Chicken Inn
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Improvement of cryopreserved rooster semen quality by combined application of DMF and ZnO NPs

Poultry Science
Semen cryopreservation represents a pivotal technology for the long-term conservation and efficient utilization of poultry genetic resources. The primary challenge impeding the implementation of this technology pertains to the phenomenon of frozen-thaw ...
Pingquan Liu, Jianing Liu, Mingzhen Xu, Mengyao Wang, Wenjie Liang, Wenting Li, Xiangtao Kang, Hangran Gao, Huayuan Liu, Zhunan Li, Guirong Sun   +10 more
doaj   +1 more source

Coon Chicken Inn Menu Cover and Back

, 1940
Color photograph menu for Coon Chicken Inn features stereotypical depiction of an african american hotel ...
Coon Chicken Inn
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source