Results 111 to 120 of about 14,798 (236)
Co-infection with Chikungunya virus alters trafficking of pathogenic CD8(+) T cells into the brain and prevents Plasmodium-induced neuropathology [PDF]
, 2018 Arboviral diseases have risen significantly over the last 40 years, increasing the risk of co‐infection with other endemic disease such as malaria. However, nothing is known about the impact arboviruses have on the host response toward heterologous ...
Claser, Carla +8 more
core +1 more source
Advanced Science, Volume 12, Issue 47, December 18, 2025.Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding +15 more
wiley +1 more source
Journal of VirologyABSTRACT As outbreaks of chikungunya virus (CHIKV), a mosquito-borne alphavirus, continue to present public health challenges, additional research is needed to generate protective and safe vaccines and effective therapeutics.
Megan M. Stumpf +4 more
openaire +3 more sources
Targeting functional RNA structures in CHIKV and ZIKV
Access Microbiology, 2019 Emerging arboviruses such as Zika virus (ZIKV) and Chikungunya virus (CHIKV) represent a significant threat to human health and have a high potential to cause outbreaks in the near future. At present, there are no specific antivirals available for either of these important pathogens, despite the wide global prevalence of their vector, Aedes spp ...
Oliver Prosser +3 more
openaire +1 more source
VirusesDengue (DENV) and Chikungunya (CHIKV) viruses can be transmitted simultaneously by Aedes mosquitoes, and there may be co-infections in humans. However, how the adaptive immune response is modified in the host has yet to be known entirely.
Araceli Posadas-Mondragón +9 more
doaj +1 more source
A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential
PLoS Pathogens, 2007 Chikungunya virus (CHIKV) is an emerging arbovirus associated with several recent large-scale epidemics. The 2005–2006 epidemic on Reunion island that resulted in approximately 266,000 human cases was associated with a strain of CHIKV with a mutation in ...
Konstantin A. Tsetsarkin +3 more
semanticscholar +1 more source
Identification of TPRA1 as a Novel Receptor and Predictive Biomarker for Oncolytic Virus M1
Advanced Science, Volume 12, Issue 48, December 29, 2025.This study identifies transmembrane protein adipocyte‐associated 1 (TPRA1) as a novel receptor for oncolytic virus M1 (OVM). TPRA1's ectodomain binds OVM particles, while its intracellular domain facilitates virus internalization, promoting efficient viral entry.
Linyi Hu +20 more
wiley +1 more source
Seroprevalence of Chikungunya Virus after Its Emergence in Brazil. [PDF]
, 2018 Chikungunya has had a substantial impact on public health because of the magnitude of its epidemics and its highly debilitating symptoms. We estimated the seroprevalence, proportion of symptomatic cases, and proportion of chronic form of disease after ...
Barreto, Florisneide R +15 more
core +1 more source
Electroanalysis, Volume 37, Issue 12, December 2025.An electrochemical biosensor for Zika virus (ZIKV) detection is described. A DNA probe was immobilized on a gold electrode. After hybridization with the target (ZIKV), safranin was used as an intercalating indicator. Detection was performed by differential pulse voltammetry (DPV), where the current signal increases with the target concentration.
Luiz F. G. Luz +3 more
wiley +1 more source
Nature CommunicationsChikungunya virus (CHIKV), a mosquito-borne alphavirus, causes acute febrile illness that can progress into chronic arthritis-like disease (CHIKVD) in humans.
Rimjhim Agarwal +16 more
doaj +1 more source