Results 51 to 60 of about 7,187,721 (303)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Whanau Whakapakari: a Māori-centred approach to child rearing and Parent-training programmes [PDF]

, 2001
The goal of this Whanau Whakapakari (Strengthening Families) research was to define critical aspects of Māori experiences and views on child-rearing practices, and to describe whanau (extended family) values and expectations for tamariki (children) and ...
Herbert, Averil May Lloyd
core  

The effectiveness and cost-effectiveness of parent training/education programmes for the treatment of conduct disorder, including oppositional defiant disorder, in children [PDF]

, 2005
Objectives: To assess the clinical and cost-effectiveness of parent training programmes for the treatment of children with conduct disorder ( CD) up to the age of 18 years. Data sources: Electronic databases. Review methods: For the effectiveness
Dretzke, J., C Davenport, Sandercock, J., Frew, E., Taylor, R., Raftery, James, S Stewart-Brown, C Hyde, Barlow, J., J Sandercock, S Bayliss, Stewart-Brown, S., J Barlow, Hyde, C., Bayliss, S.; id_orcid, Stewart-Brown, Sarah L., J Raftery, R Taylor, Davenport, C., J Dretzke, Barlow, Jane, Bayliss, S., Taylor, Rodney, Davenport, C.; id_orcid, Frew, E.; id_orcid, Raftery, J., E Frew   +26 more
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

A chain mediation model of parent child relationship and academic burnout of adolescents

Scientific Reports
This paper studied the relationship and mechanisms of parent–child relationship, interpersonal relationship on campus, academic self-efficacy and academic burnout among adolescents. A study of 913 Chinese junior high school students from Fujian province (
Jiangnan Sun, Hang Guo, Wenxin Jiang, Xiuqing Chen, Fengyao Wu, Zisen Zhuang, Zhangya Lin   +6 more
doaj   +1 more source

Birr al-Walidain Konsep Relasi Orang Tua dan Anak dalam Islam [PDF]

Buletin Psikologi, 2017
n the family, parent-child relationship deemed to be a complicated relationship. Parents as adult individuals who have the necessity to educate will tend to straighten up their children.
Nur I'anah
doaj  

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

The effect of family oriented problem solving curriculum education on parent-child relationship elementary School Students [PDF]

Faṣlnāmah-i Farhang Mushavirah va Ravān/Darmānī, 2016
The aim of present study was to determine of the effectiveness of family oriented problem solving education on parent-child relationship among students of elementary schools in Kermanshah city.
kivan kakabaraee
doaj   +1 more source