Results 31 to 40 of about 1,908,096 (307)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Evaluation of the Physical Child Abuse [Fiziksel Cocuk Istismarinin Incelenmesi]

Medicine Science, 2014
Child abuse is the implementation of an unacceptable behavior to child by an adult in a certain period in that culture. Generally, the child abuse and neglect is defined as any kind of behavior that impacts growth and development of the child adversely ...
Fatma Yucel Beyaztas, Bahadir Ozen, Celal Butun   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Child Abuse: Knowledge and Attitudes Among Pedodontics in Uberlandia e Araguari, Minas Gerais [PDF]

Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2006
Objective: To identify from pediatric dentistry educational experiences and knowledge concerning child abuse/neglect, numbers of suspected cases of child abuse and knowledge of local child protection.
Janaína Fernandes SANTOS, Karina Silva NUNES, Alessandro Leite CAVALCANTI, Edméia Costa e SILVA   +3 more
doaj  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The mediating role of posttraumatic stress reactions in the relationship between child abuse and physical health complaints in adolescence and young adulthood

European Journal of Psychotraumatology, 2019
Background: Child abuse is associated with physical health problems in adolescence and adulthood, but the mechanisms involved are unclear. A possible mediating effect of posttraumatic stress reactions (PTSR) linking child abuse with later physical health
Janne Rueness, Mia C. Myhre, Ida Frugård Strøm, Tore Wentzel-Larsen, Grete Dyb, Siri Thoresen   +5 more
doaj   +1 more source

Unemployment and child abuse. [PDF]

BMJ, 1987
The employment state of men living in the homes of children at the time that child abuse was diagnosed was determined. The series included a wide range of abuse, including non-accidental injury, failure to thrive, neglect, and emotional deprivation. Two cohorts of children seen during 1974-9 and 1980-5 were compared; these periods were chosen because a
L S, Taitz, J M, King, J, Nicholson, M, Kessel   +3 more
openaire   +3 more sources

Redress and civil litigation report [PDF]

, 2015
The Royal Commission has examined the extent to which ‘justice for victims’ of institutional child abuse has been, or can be, achieved through previous and current redress processes and civil litigation systems.
Royal Commission into Institutional Responses to Child Sexual Abuse
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source