Results 131 to 140 of about 5,568,555 (309)
, 1911 Photo from "Lewis Hine : Photographs of Child Labor in the New South," edited by John R. Kemp (University Press of Mississippi, 1986), p. 87.
Hine, Lewis Wickes, 1874-1940; Kemp, John R., 1945-
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
, 2012 Updated irregularly; Began in 2002?; Title from home page (publisher's Web site, viewed Nov. 7, 2011).; At head of title: State of Connecticut.; Official web site of the Connecticut Office of the Child Advocate.
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
, 2012 This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on May 2, 2014)Mode of access:
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PARENTAL INFLUENCES ON CHILD WEIGHT LOSS: PERCEPTION, WILLINGNESS TO CHANGE, AND BARRIERS [PDF]
, 2013 Parents are a primary contributor to the development of obesegenic behavior in youth. However, many parents do not perceive their child’s weight to be a problem, are not ready to make changes, and may be overwhelmed by obstacles to behavior change ...
White, David
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, 2015 Updated irregularly; Began in 2002?; Title from home page (publisher's Web site, viewed Nov. 7, 2011).; At head of title: State of Connecticut.; Official web site of the Connecticut Office of the Child Advocate.
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Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
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Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Description based on: Issue 12 (Nov./Dec. 1996); title from caption.Not distributed to depository libraries in a physical form, Issue 23, 2000-Previously classed: HE 23.1017:Mode of access: Internet.Published by the National Child Care Information Center
United States. Child Care Bureau. +1 more
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