Results 71 to 80 of about 1,182,149 (391)

Stable prediction of mood and anxiety disorders based on behavioral and emotional problems in childhood: a 14-year follow-up during childhood, adolescence, and young adulthood [PDF]

, 2003
OBJECTIVE: The goal of this study was to predict the onset of mood and anxiety disorders from parent-reported emotional and behavioral problems in childhood across a 14-year period from childhood into young adulthood.
Ende, J. (Jan) van der, Hofstra, M.B. (Marijke), Roza, S.J. (Sabine), Verhulst, F.C. (Frank)   +3 more
core   +2 more sources

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

FEBS Letters, Volume 599, Issue 7, Page 971-988, April 2025.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin, Danielle M. Colussi, Peter B. Stathopulos   +2 more
wiley   +1 more source

Conformities of Origin and Prevalence of Mental Disorders among Child Population in Conditions of Modern Donbass

Zdorovʹe Rebenka, 2013
The primary mental disorders morbidity in child population (0–17 years old) is within 41.8 ± 0.1 cases on 10 000 persons and overruns a total average regional index. The prevalence of the diseases associated with behavior and mental disorders among child
V.I. Аgarkov, Ye.I. Yevtyshenko, A.A. Mustafina, P.V. Kudymov   +3 more
doaj   +1 more source

Associations between Maternal and Offspring Hair Cortisol Concentrations and Child Behavioral Symptoms in Mother-Child Pairs with Perinatal Mental Disorders

Children, 2022
Maternal perinatal mental disorders (PMD) are associated with developmental and behavioral problems in children, probably mediated by the programming of the hypothalamic–pituitary–adrenal (HPA) axis. Increased cortisol concentrations during the antenatal
Anna Agapaki, Fenia Papagianni, Dimitra Metallinou, Eleni Valavani, Aimilia Mantzou, Stamatia Kanelli, Makarios Eleftheriades, Areti C. Spyropoulou, Ioannis Zervas, George P. Chrousos, Panagiota Pervanidou   +10 more
doaj   +1 more source

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

Disruptive Behavior Disorders in 8 to 14 Years Old Offspring’s of Opium and Heroin Dependent Parents: a Case-Control Study [PDF]

Addiction and Health, 2010
Background:Drug abuse is usually associated with behavioral disorders in children especially conduct disorder. This study investigated the behavioral disorders of children whose parents were opium or heroin dependent in compare with children whose
Mahin Eslami Shahrbabaki, Hassan Ziaaddini, Hamdollah Saieedi, Nouzar Nakhaiee   +3 more
doaj  

Mediators of the relation between maternal depressive symptoms and child internalizing and disruptive behavior disorders.

Journal of family psychology, 2003
Drawing on a normative sample of 224 youth and their biological mothers, this study tested 4 family variables as potential mediators of the relationship between maternal depressive symptoms in early childhood and child psychological outcomes in ...
C. McCarty, R. McMahon
semanticscholar   +1 more source

Screening for Significant Behavior Problems in Diverse Young Children Living in Poverty [PDF]

, 2016
The development and use of first line screening instruments is an essential first step in assessing behavior disorders in very young children. The Early Childhood Behavior Screen (ECBS) is a parent-report measure for behavior disorders and is normed on ...
Fox, Robert A., Harris, Sara E., Holtz, Casey A.   +2 more
core   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source