Results 51 to 60 of about 584,631 (308)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Cadernos de Saúde Pública, 1999 Foram identificadas 92 creches (23 públicas, 10 filantrópicas e 59 privadas) no Município de Pelotas, Rio Grande do Sul, das quais se estudaram aspectos da organização, práticas de cuidado e estrutura física.
Aluísio J. D. Barros +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Nordisk Barnehageforskning, 2012 : The purpose of the presented study is to explore whether ITERS-R is an appropriate tool to use for examining the quality of care for infants and toddlers in Norwegian day care centers.
Anne-Grethe Baustad
doaj +1 more source
Surveying of respiratory and GI infections symptoms of preschool children at child day care centers and family day care according to parents report in Ardebil between 2006 to 2009 years [PDF]
Introduction:As more mothers have to work out of home, therefore increasing numbers of their children are being placed in out of home child care as day care centre.
اصلانی, محمدرضا +3 more
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
[Child care according to day care center workers].
Revista latino-americana de enfermagem, 2003 This investigation aimed at understanding and analyzing the representations of the workers from daycare centers regarding the care they provide to children. Data were collected through individual interviews and an educational workshop. These interviews were carried out in daycare centers, that are associated to a public university in the municipality ...
Maria De La O Ramallo, Veríssimo +1 more
openaire +1 more source
Poor infant feeding practices and high prevalence of malnutrition in urban slum child care centres in nairobi: a pilot study [PDF]
, 2015 Little is known about the style and quality of feeding and care provided in child day-care centres in slum areas. This study purposively sampled five day-care centres in Nairobi, Kenya, where anthropometric measurements were collected among 33 children ...
Garcia, Ada L. +4 more
core +1 more source