Results 51 to 60 of about 110,490 (301)

PREVALÊNCIA E FATORES ASSOCIADOS À PRÁTICA DA AMAMENTAÇÃO DE CRIANÇAS QUE FREQÜENTAM UMA CRECHE COMUNITÁRIA

Ciencia y Enfermería
É inquestionável o valor do leite materno como fonte nutricional exclusiva para a criança nos primeiros seis meses de vida, onde dentre vários benefícios evidencia-se a prevenção da morbi-mortalidade infantil.
Maria Helena do Nascimento Souza, Vitória Regina Domingues Sodré, Fabíola Nogueira Ferreira da Silva   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Health Management Status of Day Care Centers [PDF]

, 2008
Purpose: This study was conducted to identify the status of health management and to evaluate the need for health professionals in day care centers in the South Korea.
최은경, 김희순, 이혜정
core  

Effects of early child-case on cognition, language, and task-related behaviours at 18 months: an English study

, 2011
This study investigated the effects of different characteristics of early child-care in England on the development of cognition, language, and task-related attention and behaviour (orientation/engagement and emotion regulation during the Bayley ...
Malmberg, L.E., Jacqueline Barnes, Alan Stein, Kathy Sylva, Stein, A, Sylva, K, Sylva, K., Sylva, Kathy, Barnes, Jacqueline, Families, Children and Child-Care (FCCC) team, null null, Stein, A., Stein, Alan, Leach, P, Leach, Penelope, Malmberg, Lars, Barnes, J, Penelope Leach, Malmberg, LE, Malmberg, Lars-Erik, Lars-Erik Malmberg   +20 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Perfil das creches de uma cidade de porte médio do sul do Brasil: operação, cuidados, estrutura física e segurança Daycare centers in a medium-sized Brazilian city: operations, child-care practices, infrastructure, and safety

Cadernos de Saúde Pública, 1999
Foram identificadas 92 creches (23 públicas, 10 filantrópicas e 59 privadas) no Município de Pelotas, Rio Grande do Sul, das quais se estudaram aspectos da organização, práticas de cuidado e estrutura física.
Aluísio J. D. Barros, Evandro V. Gonçalves, Cátia R. S. de Borba, Cláudia S. Lorenzatto, Débora B. Motta, Vera Regina L. da Silva, Viviane M. Schiroky   +6 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Measles Information for Child Care Centers [PDF]

Childcare center staff and children should be protected against measles and get vaccinated, if needed, according to their age and health status.

core  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source