Results 141 to 150 of about 19,247,752 (396)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Implementation of a parent training intervention (SPARCK) to prevent childhood mental health problems: study protocol for a pragmatic implementation trial in Norwegian municipalities

Trials
Background Effective evidence-based interventions (EBI) are necessary to prevent and avoid negative life trajectories for children with mental health problems.
Anette Arnesen Grønlie, Agathe Backer-Grøndahl, Ragnhild Bang Nes, Maria Begoña Gomez, Truls Tømmerås   +4 more
doaj   +1 more source

Factors Affecting Employee Job Satisfaction of Women and Child Development, Government of India, A Case Study (Faridabad, Haryana)

, 2016
Esha Singh
openalex   +1 more source

Interventions to reduce inequalities in health and early child development in Europe from a qualitative perspective [PDF]

, 2016
Joana Morrison, Hynek Pikhart, Peter Goldblatt   +2 more
openalex   +1 more source

Pedagogy of child development in the Kichwa nationality of Pastaza and incidence in the formulation of the initial level curriculum

, 2022
Fernando Alberto, Yánez Balarezo
openalex   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Early detection of students’ mental health issues from a traditional daily health observation scheme in Japanese schools and its digitalization

Frontiers in Public Health
ObjectiveThe implementation of school-based mental health screening offers promise for early detection of mental health issues in children; however, various barriers hinder its widespread adoption.
Tomoko Nishimura, Tomoko Nishimura, Tomoko Nishimura, Manabu Wakuta, Manabu Wakuta, Yuko Osuka, Yuko Osuka, Nobuaki Tsukui, Nobuaki Tsukui, Nobuaki Tsukui, Ikue Hirata, Ikue Hirata, Michio Takahashi, Michio Takahashi, Masaki Adachi, Masaki Adachi, Taiichi Katayama, Taiichi Katayama, Kyoko Aizaki, Kyoko Aizaki, Motofumi Sumiya, Motofumi Sumiya, Sayaka Kawakami, Sayaka Kawakami, Toshiki Iwabuchi, Toshiki Iwabuchi, Atsushi Senju, Atsushi Senju   +27 more
doaj   +1 more source

Uzbekistan Supplementary NGO Report on the Implementation of the Convention on the Rights of the Child in the Republic of Uzbekistan [PDF]

, 2001
[Excerpt] The Convention on the Rights of the Child (CRC) was one of the first international instruments to which the Republic of Uzbekistan acceded, and with parliamentary ratification on 9 December 1992, the Republic of Uzbekistan entered into a ...

core   +1 more source