Results 151 to 160 of about 19,247,752 (396)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Predictors of caregiver support intervention outcomes for refugees in Jordan: a three-path mediational study

Child and Adolescent Psychiatry and Mental Health
Background More evidence is needed for understanding how evidence-based psychological interventions work, especially when implemented by briefly trained non-professionals in low- and middle-income settings. The nine-session caregiver support intervention
M. J. D. Jordans, G. V. Koppenol-Gonzalez, H. Al Hmoud, A. F. Guevara, F. Steen, H. Mansour, B. A. Kohrt   +6 more
doaj   +1 more source

Official Development Assistance and Private Voluntary Support for Reproductive, Maternal, Neonatal, and Child Health in Guinea-Bissau: Assessing Trends and Effectiveness [PDF]

Anaxore Casimiro, José Roberto Tavares Branco, Réka Maulide Cane, Michel Jareski Andrade, Luís Varandas, Isabel Craveiro   +5 more
openalex   +1 more source

Increasing Prevention of Mother to Child Transmission (PMTCT) Uptake through Facility-Based Health Promotion: Intervention Development [PDF]

, 2023
Ibrahim Elsiddig Elsheikh, Rik Crutzen, Ishag Adam, Salah Ibrahim Abdelraheem, H.W. van den Borne   +4 more
openalex   +1 more source

Survival Convergence: Specification Matters [PDF]

Retaining as a “Millennium Development Goal” a decrease by two thirds in child mortality whatever its initial level assumes that the target elasticity of child mortality may be the same in all the developing countries.
Christopher Grigoriou
core  

Latina Women in the United States: Child Care Preferences and Arrangements [PDF]

, 2017
Formal child care has been associated with myriad benefits for children, such as improvements in cognitive development and language skills. Immigrant children may derive unique benefits from formal child care, as research has also confirmed that center ...
Banik, Rumeli, Ph.D., Roubeni, Sonia, M.A., Satkowski, Laura, Ph.D.   +2 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The rescue, reform and restoration of childhood : a hundred years of child labour in Britain (1780-1880) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Social Anthropology at Massey University, Palmerston North, New Zealand [PDF]

, 2003
Over the past twenty years, child labour has drawn heightened attention from the global community, especially through debates over labour standards and international trade.
Stillman, Terry
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Growth and Development among Patients with Pierre Robin Sequence: National Center for Child Health and Development (Tokyo, Japan) Experience

Plastic and Reconstructive Surgery, Global Open, 2021
Makoto Hikosaka, MD, Tsuyoshi Kaneko, MD, Eri Matoba, MD, Tomohisa Nagasao, MD, Wataru Tsugu, MD   +4 more
doaj   +1 more source