Results 41 to 50 of about 19,059,317 (408)

Integrating Early Child Development and Violence Prevention Programs: A Systematic Review.

New Directions for Child and Adolescent Development, 2018
Limited evidence describes promoting development and reducing violence in low- and middle-income countries (LMICs), a missed opportunity to protect children and promote development and human capital.
Yvette Efevbera, D. McCoy, Alice J. Wuermli, T. Betancourt   +3 more
semanticscholar   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Study protocol for a randomized controlled trial of supportive parents – coping kids (SPARCK)—a transdiagnostic and personalized parent training intervention to prevent childhood mental health problems

BMC Psychology
Background To meet the scientific and political call for effective prevention of child and youth mental health problems and associated long-term consequences, we have co-created, tested, and optimized a transdiagnostic preventive parent-training ...
T. Tømmerås, A. Backer-Grøndahl, A. Høstmælingen, H. Laland, M. B. Gomez, A. Apeland, L. R. A. Karlsson, A. A. Grønlie, S. Torsvik, G. E. Bringedal, Advisory Consortium, Aas Monica, Phillip Andrew Fisher, Frances Gardner, John Kjøbli, Ira Malmberg-Heimonen, Helene Amundsen Nissen-Lie   +16 more
doaj   +1 more source

A multi-modal MRI analysis of brain structure and function in relation to OXT methylation in maltreated children and adolescents

Translational Psychiatry, 2021
Child maltreatment dysregulates the brain’s oxytocinergic system, resulting in dysfunctional attachment patterns. However, how the oxytocinergic system in children who are maltreated (CM) is epigenetically affected remains unknown.
Shota Nishitani, Takashi X. Fujisawa, Daiki Hiraoka, Kai Makita, Shinichiro Takiguchi, Shoko Hamamura, Akiko Yao, Koji Shimada, Alicia K. Smith, Akemi Tomoda   +9 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Expert Consensus on Active Health Management of Short Stature Based on the Integration of Sports, Healthcare and Education(2025 Edition)

Xiehe Yixue Zazhi
Short stature is a disease that affects children's physical and psychological health, closely associated with lifestyle factors such as diet, physical activity, and sleep.
China Behavioral Medical Research Center for Growth and Development, Behavioral Medicine Branch of Chinese Medical Association Committee on Growth, Development and Metabolism, China Maternal and Child Health Research Association
doaj   +1 more source

Is there a place for work in child development? Implications of child development theory and research for interpretation of the UN Convention on the Rights of the Child, with particular reference to Article 32, on children, work and exploitation [PDF]

, 1999
This paper is about the role of child-development knowledge and research in international efforts to improve the lives and prospects for millions of working children.
Woodhead, Martin
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

First-in-human clinical study of an embryonic stem cell product for urea cycle disorders

Stem Cell Research & Therapy
Background This study assesses the safety and efficacy of hepatocyte-like cell (HLC) infusion therapy derived from human embryonic stem cells as bridging therapy for neonatal-onset urea cycle disorders (UCD).
Akihiro Umezawa, Akinari Fukuda, Reiko Horikawa, Hajime Uchida, Shin Enosawa, Yoshie Oishi, Naoko Nakamura, Kengo Sasaki, Yusuke Yanagi, Seiichi Shimizu, Toshimasa Nakao, Tasuku Kodama, Seisuke Sakamoto, Itaru Hayakawa, Saeko Akiyama, Noriaki Saku, Shoko Miyata, Kenta Ite, Palaksha Kanive Javaregowda, Masashi Toyoda, Hidenori Nonaka, Kazuaki Nakamura, Yoshikazu Ito, Yasuyuki Fukuhara, Osamu Miyazaki, Shunsuke Nosaka, Kazuhiko Nakabayashi, Chizuko Haga, Takako Yoshioka, Akira Masuda, Takashi Ohkura, Mayu Yamazaki-Inoue, Masakazu Machida, Rie Abutani-Sakamoto, Shoko Miyajima, Hidenori Akutsu, Yoichi Matsubara, Takashi Igarashi, Mureo Kasahara   +38 more
doaj   +1 more source

Consensus on the Establishment and Operational Standards of Standardized Growth-and-Development Medical Centers Based on Active Health Principles (2025)

Xiehe Yixue Zazhi
With accelerated socioeconomic development and structural lifestyle changes, childhood and adolescent growth and developmental disorders in China have exhibited increasing complexity and a trend toward earlier onset, while the incidence of certain ...
China Behavioral Medical Research Center for Growth and Development, Behavioral Medicine Branch of Chinese Medical Association, Committee on Growth, Development and Metabolism, China Maternal and Child Health Research Association   +1 more
doaj   +1 more source