Results 51 to 60 of about 974,916 (295)

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Salivary oxytocin concentrations in seven boys with autism spectrum disorder received massage from their mothers: a pilot study

Frontiers in Psychiatry, 2015
Seven male children with autism spectrum disorder (ASD), aged 8 – 12 years, attending special education classrooms for ASD and disabled children, were assigned to receive touch therapy. Their mothers were instructed to provide gentle touch in the massage
Shuji eTsuji, Teruko eYuhi, Kazumi eFuruhara, Shogo eOhta, Yuto eShimizu, Haruhiro eHigashida   +5 more
doaj   +1 more source

Intrapericardial immature teratoma with pericardial effusion in a 4-month-old boy

Journal of Pediatric Surgery Case Reports, 2020
Intrapericardial teratoma is an extremely rare mediastinal teratoma that arises at the junction of the ascending aorta and right atrial appendage. The teratoma is often complicated by massive pericardial effusion that compresses the heart and lungs ...
Teizaburo Mori, Kazue Miyake, Yumi Kudo, Takuro Fujita, Mai Kutsukake, Yohei Yamada, Kazunori Tahara, Akihiro Fujino, Ryoichi Kondo, Yukihiro Kaneko, Yuki Saito, Keita Terashima, Kimikazu Matsumoto, Takako Yoshioka, Yutaka Kanamori   +14 more
doaj   +1 more source

Poverty and Child Development [PDF]

Developmental Medicine & Child Neurology, 1968
SUMMARYThe effects of poverty on child development are looked at by reference to other social indices, such as the statistical returns of the Registrar General. These effects begin before birth with higher rates among the poor of still‐birth, abortion, prematurity, perinatal mortality and the risk of congenital malformations.
Gillian Yudkin, Simon Yudkin
openaire   +3 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACI Study)—protocol for a randomized controlled trial

Clinical and Translational Allergy, 2018
Background Atopic dermatitis is the first clinical manifestation of the atopic march, with the highest incidence in the first year of life. Those affected often go on to develop other allergic diseases including food allergy, asthma, and allergic ...
Kiwako Yamamoto-Hanada, Tohru Kobayashi, Hywel C. Williams, Masashi Mikami, Mayako Saito-Abe, Kumiko Morita, Osamu Natsume, Miori Sato, Motoko Iwama, Yumiko Miyaji, Makiko Miyata, Shinichiro Inagaki, Fukuie Tatsuki, Narita Masami, Shoji F. Nakayama, Hiroshi Kido, Hirohisa Saito, Yukihiro Ohya   +17 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source