Results 91 to 100 of about 24,028 (258)

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

Advanced Science, EarlyView.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen   +14 more
wiley   +1 more source

Executive dysfunction in autism [PDF]

, 2004
‘Executive function’ is an umbrella term for functions such as planning, working memory, impulse control, inhibition and mental flexibility, as well as for the initiation and monitoring of action. The primacy of executive dysfunction in autism is a topic
Hill, Elisabeth L.
core   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

The work of health visitors and school nurses with children with psychological and behavioural problems [PDF]

, 2008
<b>Aim</b>. This paper is a report of a study to describe the workload of health visitors and school nurses in relation to children and young people with psychological, emotional or behavioural problems, and to identify perceived challenges ...
Wilson, Paul, Graham Bryce, Barbour, R., Bryce, Graham, Philip Wilson, Connelly, G., Phin, L., Furnivall, Judy, Barbour, Rose, Judy Furnivall, Phin, Louise, Anna Stallard, Stallard, Anna, Stallard, A., Furnivall, J., Connelly, Graham, Bryce, G., Barbour, Rosaline S., Rosaline S. Barbour, Wilson, Philip, Louise Phin, Graham Connelly, Barbour, Rosaline   +22 more
core   +1 more source

Evaluating the Impact of Early Intervention on Developmental Outcomes in Children with Autism Spectrum Disorder: A Comparative Study in Bangladesh

Asia Pacific Journal of Health Management
Introduction: Autism Spectrum Disorder (ASD) presents a range of developmental challenges, often impacting social, cognitive, and motor skills. Early intervention (EI) is essential in supporting children with ASD by leveraging neuroplasticity during ...
Anika Ferdous, MD Nahid Hassan Nishan , Siva Ganesan   +2 more
doaj  

Modified MXene Aerogel With Broadband Microwave Absorption Inspired by Melanophila Acuminata Beetle

Advanced Science, EarlyView.
This work introduces a novel biomimetic strategy inspired by the infrared‐sensing sensilla of the Melanophila acuminata beetle. We have designed a multi‐level aerogel, featuring a three‐dimensional carbon framework decorated with synergistic CeO2 nanoparticles and Ti3C2Tx MXene nanosheets.
Zhiwei Liu, Dingyu Xu, Zhaobo Liu, Haitian Song, Qianqian Zhang, Junxiao Zhou, Xiewen Wen   +6 more
wiley   +1 more source

Sleep, anxiety and challenging behaviour in children with intellectual disability and/or autism spectrum disorder [PDF]

, 2011
Children with an intellectual disability (ID) and/or autism spectrum disorder (ASD) are known to suffer from significantly more sleep problems, anxiety and challenging behaviour (CB) than typically developing children (TD), yet little is known about the ...
Rzepecka, Halina, McClure, Iain, Karen McKenzie, Iain McClure, Halina Rzepecka, McKenzie, Karen, Murphy, Shona, Shona Murphy   +7 more
core   +1 more source

Flanking‐Group Engineering Unlocks Emerging Functionalities in Diketopyrrolopyrrole Semiconductors

Advanced Science, EarlyView.
This review presents a comprehensive and unified perspective of flanking‐group engineering in Diketopyrrolopyrrole (DPP) based organic semiconductors that connects molecular‐level design with cross‐device functionalities. By integrating insights from molecular design, solid‐state packing, and device physics, this review seeks to establish general ...
Xiaoyun Wu, Shanshan Zhou, Meng Li, Aung Ko Ko Kyaw, Xiao‐Lei Shi, Qian Liu   +5 more
wiley   +1 more source

Wayfinding in autism spectrum disorders [PDF]

, 2011
This study featured the use of ... a comprehensive battery [of tests], designed to assess general spatial ability as well as varieties of spatial cognition (including spatial navigation)
Ing, Natalia, Natalia Ing
core