Results 51 to 60 of about 16,240,857 (298)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Scientifica, 2016 We examined parent-reported adverse childhood experiences (ACEs) and associated outcomes among American Indian and Alaska Native (AI/AN) children aged 0–17 years from the 2011-2012 National Survey of Children’s Health.
Mary Kay Kenney, Gopal K. Singh
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
BJPsych BulletinAims and method Cognitive analytic therapy (CAT) is a relational, time-limited psychotherapy primarily evidenced to support adults with emotional and relational difficulties. The extent of evidence for CAT in younger populations is not known.
Emma Salter +3 more
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BMC Research Notes, 2018 Objective Sub-Saharan Africa has the highest prevalence of children at risk of not achieving their developmental potential, attributable largely to the human immunodeficiency virus (HIV) pandemic coupled with negative environmental factors.
Renate Strehlau +2 more
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The amniotic fluid cell-free transcriptome in spontaneous preterm labor
Scientific Reports, 2021 The amniotic fluid (AF) cell-free RNA was shown to reflect physiological and pathological processes in pregnancy, but its value in the prediction of spontaneous preterm delivery is unknown.
Gaurav Bhatti +9 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The association between salivary oxytocin, age, and puberty in children with and without OCD
Scientific ReportsThe oxytocin system has been thought to contribute to obsessive-compulsive disorder (OCD). Few studies, only involving adults, have investigated this hypothesis and have found inconsistent results regarding oxytocin system activity and OCD.
Anna-Rosa Cecilie Mora-Jensen +19 more
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Cyclical vomiting syndrome in a 10 year old girl: a case report
Sri Lanka Journal of Psychiatry, 2012 A 10 year old girl presented with repeated episodes of vomiting over a one year period. She had intense nausea and severe vomiting, occurring in cycles which needed repeated hospital admissions, severely affecting her functioning.
Swarna Wijetunge, Manisha Dalpatadu
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source