Results 231 to 240 of about 4,625,605 (347)

Association of birth defects during the perinatal period with child mortality under 5 years. [PDF]

Front Pediatr
Xie D, Wei J, Xiong L, Zhu H, Peng X, Li B, Zou K.   +6 more
europepmc   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Infant and Child Mortality in Afghanistan Wheat and Chaff. [PDF]

Health Sci Rep
Chirumbolo S.
europepmc   +1 more source

TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6–GAS6 Axis

Advanced Science, EarlyView.
This study shows TGM2 is upregulated in AP, impairing macrophage efferocytosis by inhibiting the STAT6–GAS6 axis. The lactoferrin‐modified, ROS‐responsive LF‐LNP@si‐TGM2 targets pancreatic macrophages, silences TGM2, restores the axis, and alleviates AP.
Xuxu Liu, Zhiwei Du, Liyi Wang, Zhihong Xie, Ziang Meng, Yi Zheng, Heming Wang, Yuanhang He, Dongbo Xue   +8 more
wiley   +1 more source

Changes in child mortality and population health following 10 years of health systems strengthening in rural Madagascar: A longitudinal cohort study. [PDF]

PLoS Med
Garchitorena A, Miller AC, Razanadranaivo HL, Rakotonirina L, Barriault SA, Razafinjato B, Kotchofa JA, Rafenoarimalala F, Rakotonanahary RJL, Ihantamalala FA, Evans MV, Tolojananahary AT, Ramanandraitsiory V, Tsitinomen'nyaina A, Ralaivavikoa FA, Raza-Fanomezanjanahary EM, Randriamanambintsoa M, Andrianambinina S, Yasmine LL, Murray MB, Rich ML, Cordier LF, Finnegan KE, Bonds MH, Randriamanantany ZA.   +24 more
europepmc   +1 more source

Reducing child mortality [PDF]

The Indian Journal of Pediatrics, 2001
openaire   +1 more source

The resource curse and child mortality, 1961-2011.

Social Science & Medicine (1967), 2017
S. Wigley
semanticscholar   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Assessing the impact of COVID-19 pandemic on all-cause mortality and child mortality in a population cohort of Iganga Mayuge HDSS in Eastern Uganda (2015-2021). [PDF]

Popul Health Metr
Kajungu D, Nabukeera B, Bashingwa J, Kabudula C, Barr BT, Ndyomugyenyi D, Consolate AM, Gyezaho C, Rutebemberwa E.   +8 more
europepmc   +1 more source

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source