Results 81 to 90 of about 1,377,555 (289)

Child abuse, child protection and disabled children : a review of recent research [PDF]

, 2012
This paper reports the results of a scoping study which reviewed research about child abuse, child protection and disabled children published in academic journals between 1996 - 2009. The review was conducted using a five stage method for scoping studies.
Agnew, Akbas, Alderson, Aniol, Arksey, Balogh, Barnard, Briggs, Cederborg, Cederborg, Cooke, Firth, Giardino, Govindshenoy, Hershkowitz, Hollins, Jarosz, Jaudes, Jemta, Kapitanoff, Knutson, Kvam, Kvam, Kvam, Lightfoot, Manders, Mansell, Mitchell, Monahan, Morris, Reiter, Romney, Rosenberg, Ryan, Sequeira, Sequeira, Shannon, Sobsey, Spencer, Stalker, Sullivan, Sullivan, Westcott   +42 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Protect My Future: The Links Between Child Protection and Equity [PDF]

, 2012
The lack of care and protection facing children is a global crisis with billions of children experiencing abuse, neglect or exploitation, and many millions growing up outside of families, on the streets or in harmful institutional care.
Andy West, Emily Delap
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Embedding violence prevention in existing religious and education systems: initial learning from formative research in the Safe Schools Study in Zimbabwe

BMC Public Health
Background Few interventions to reduce violence against children in Catholic Church affiliated schools have been tested for effectiveness. We describe learning from formative research on the development of a school-based behavioural intervention aiming ...
Emily Eldred, Ellen Turner, Camilla Fabbri, Amiya Bhatia, Michelle Lokot, Tendai Nhenga, Charles Nherera, Progress Nangati, Ratidzai Moyo, Dorcas Mgugu, Robert Nyakuwa, Sarah Rank, Annah Theresa Nyadombo, Karen Devries   +13 more
doaj   +1 more source

The scale and timing of child protection system contacts from 0-18 years: a study of 1.9 million Australian children

International Journal of Population Data Science
Introduction To prevent abuse, neglect and poor outcomes for children and families, including child protection intervention, maltreatment, and removals, it is critical to understand the scale and timing of child protection system contacts to identify ...
Rhiannon Pilkington, Kathleen Falster, Mark Hanly, Alicia Montgomerie, Tasnia Ahmed, BJ Newton, Ben Edwards, Raghu Lingam, Anthony Shakeshaft, Michelle Cretikos, Jessica Stewart, Katherine Hawkins, Kitty McLean, John Lynch   +13 more
doaj   +1 more source

When it comes to safeguarding children, there exists a confused story about what we think maturity is [PDF]

, 2012
In the wake of the Rochdale grooming case and questions surrounding child protection in schools, Tim Linehan discusses our misconceptions around maturity and what this means for child safeguarding.
Linehan, Tim
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source