Results 81 to 90 of about 1,385,407 (305)
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Frontiers in Public HealthIntroductionChild sexual exploitation (CSE) continues to present significant challenges for policing, with longstanding concerns about inconsistent recognition of risk, victim-blaming narratives, and uneven application of trauma-informed approaches ...
Tracee Green +2 more
doaj +1 more source
‘When One Door Shuts, Another Opens’: Turning Disadvantages into Opportunities [PDF]
, 2002 For many years, the child and family welfare and the child protection systems in the Netherlands have been under heavy criticism. Numerous experts in these fields have been advocating more intensive co-operation and a better coherence between both ...
Veldkamp, A.W.M.
core +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
The Football Association’s Child Protection in Football Research Project 2002-2006: Rationale, design and first year results [PDF]
, 2004 In common with most sport organisations, the English Football Association has come relatively recently to the issue of child protection. Abuses of various kinds have been known about in the sport for many years but, until the late 1990s, very little ...
Brackenridge, CH +6 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source
Improving practice : child protection as a systems problem [PDF]
, 2005 This paper argues for treating the task of improving the child protection services as a systems problem, and for adopting the system-focused approach to investigating errors that has been developed in areas of medicine and engineering where safety is a ...
Munro, Eileen
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley +1 more source
International Journal of Population Data ScienceIntroduction Children who experience maltreatment have worse health and development outcomes than other children. Early prevention relies on opportunities to respond to system contacts that reliably indicate the population burden of children’s future ...
Kathleen Falster +14 more
doaj +1 more source