CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Maternal child-rearing practices in Hong Kong and Beijing Chinese families: A comparative study [PDF]
, 2000 The present study aimed to examine the child-rearing practices in Chinese families in Beijing and Hong Kong. The sample consisted of 89 mothers in Beijing and 45 mothers in Hong Kong.
Lai, AC, Zhang, ZX, Wang, WZ
core
Annual Research Review: Umbrella synthesis of meta-analyses on child maltreatment antecedents and interventions: differential susceptibility perspective on risk and resilience. [PDF]
, 2019 Child maltreatment in the family context is a prevalent and pervasive phenomenon in many modern societies. The global perpetration of child abuse and neglect stands in stark contrast to its almost universal condemnation as exemplified in the United ...
Coughlan, Barry +9 more
core +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Los padres y los hijos: variables de riesgo Parents and children: risk variables
Educación y Educadores, 2007 La presente investigación estudia, dentro de la validez ecológica de la educación familiar, la relación entre conflictos maritales, prácticas de crianza y problemas de conducta de los hijos.
María Aurelia Ramírez Castillo
doaj
Parents' perspectives on the role of kin in child-rearing: a qualitative study on Greenland's universal parenting programme MANU. [PDF]
Int J Circumpolar Health, 2023 Ingemann C +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
POLA ASUH ANAK DALAM SERAT PALIATMA
Litera, 2005 This research study is intended to describe child-rearing patterns in Serat Paliatma by KGPAA Mangkunagara IV. The source of the data was Serat Paliatma, consisting 18 stanzas in pupuh Dhandhanggula (the Dhandhanggula song).
Nurhidayati Nurhidayati
doaj