Results 221 to 230 of about 2,960,828 (297)

Mepolizumab Modifies Blood Eosinophil Proteome and Transcriptome in Severe Eosinophilic Asthma

open access: yesAllergy, EarlyView.
This study investigates the effect of mepolizumab on the proteomic and transcriptomic profile of blood eosinophils in SEA patients. Mepolizumab reduces the migratory capacity and effector‐related molecular signatures of circulating eosinophils in SEA patients.
Pablo Miguéns‐Suárez   +14 more
wiley   +1 more source

Single‐Cell Omics Profiling Reveals Enhanced Heterogeneity of Cord Blood Basophils at Birth

open access: yesAllergy, EarlyView.
Cord basophils exhibit greater heterogeneity and diverse functional states relative to maternal basophils. Maternal and cord blood basophils have different transcriptomics and functional profiles. Cord basophil exhibits earlier pseudotime than maternal basophil, potentially indicating a more naïve state.
Jing Hui Low   +15 more
wiley   +1 more source

Germany's <i>Verschickungskinder</i>: parent-child separation and mental health. [PDF]

open access: yesEur J Psychotraumatol
Yim IS   +4 more
europepmc   +1 more source

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

open access: yesAndrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou   +8 more
wiley   +1 more source

Differential Sperm DNA Methylation Profiles in Healthy Men With High Versus Low Adherence to the Mediterranean Diet in the Led‐Fertyl Study

open access: yesAndrology, EarlyView.
ABSTRACT Background Diet is known to play an essential role not only in sperm quality but also in offspring health, likely mediated through the sperm epigenome. Moreover, one of the main components of the Mediterranean diet (MedDiet) (i.e., nuts) have shown to impact sperm DNA methylation patterns.
Rashmi Agarwal   +10 more
wiley   +1 more source

Pathogen‐Specific Bloodstream Infections Associated With Tumour Necrosis Factor‐α Inhibitors, Vedolizumab and Ustekinumab in Inflammatory Bowel Disease: A Danish Nationwide Case‐Control Study 2010–2024

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
In this nationwide study of patients with inflammatory bowel disease, TNF inhibitor use was associated with higher bloodstream infection rates, whereas vedolizumab and ustekinumab was not. Associations differed by pathogen species, and concomitant glucocorticoid use was associated with higher infection rates.
Cæcilie Leding   +4 more
wiley   +1 more source

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