Results 41 to 50 of about 2,960,828 (297)
University of Chitral Journal of Linguistics and Literature, 2020 African drama and theatre discourse on gender relations often address some cultural issues as salient factors that undermine the female quest to transcend marginal and debilitating spaces through self-emancipation and education.
Raphael Chukwuemeka Onyejizu
doaj +1 more source
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng +12 more
wiley +1 more source
COMMERCIAL SEXUAL EXPLOITATION OF CHILDREN: AN EFFORT OF HANDLING AND LEGAL PROTECTION
Yustisia, 2019 This article examines efforts to protect and deal with government, law enforcement agencies and assistants or NGOs in preventing and eradicating commercial sexual exploitation of children (CSEC).
Devi Rahayu, Syamsul Fatoni
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PENDIDIKAN KARAKTER BERBASIS KELUARGA
Ta'dib, 2012 The Indonesian nation is currently experiencing a degradation of almost all lines of social and moral life. The rise of cases of domestic violence, human trafficking, juvenile delinquency, "free sex", premarital sexual intercourse, corruption and so on.
Jalaluddin Jalaluddin
doaj +3 more sources
Child Trafficking in Glasgow: The Journey So Far [PDF]
, 2012 Two years after the publication of the Glasgow Child Protection Committee practice guidance for child trafficking, an audit of all cases known to the social work child protection team was undertaken.
Ball, Margaret +2 more
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SEX TRAFFICKING RECOMMENDATIONS FOR US & INTERNATIONAL POLICY [PDF]
, 2020 There are an estimated 24.9 million people being trafficked around the world (Human Trafficking, 2020). This project explores discourse and framing around trafficked individuals, particularly those trafficked for sex work, and how this influences ...
Agosta, Abigial
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Advanced Science, EarlyView.We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka +10 more
wiley +1 more source
Public and Private International Law Bulletin, 2020 Human trafficking is one of the most common problems in the world and its consequences directly affect many lives. In the annual trafficking reports published, there are millions of victims who have been forced into various situations such as forced ...
Fatma Elif Çelik
doaj +1 more source
Advanced Science, EarlyView.Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu +14 more
wiley +1 more source