Results 161 to 170 of about 26,400 (257)

Advancing Understanding of Subjective Liveability for People With Disability

Australian Journal of Social Issues, EarlyView.
ABSTRACT Modern liveability frameworks aim to enhance health and well‐being through equity‐based measures across built, natural, social, and economic environments, yet they often overlook the perspectives of people with disability. This study explored expectations of liveable neighbourhoods among adults with diverse disability experiences in urban and ...
Maria Hobbs, Kim Jose, Ceridwen Owen, Verity Cleland   +3 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Autophagy, endolysosomes and extracellular space in autoimmune and innate immune defects. [PDF]

Front Immunol
Schuler J, Tollmann L, Körner RW, Möller B, Schober E, Schöner C, Kusters M, Lim M, Niehues T, Jungbluth H, Dafsari HS.   +10 more
europepmc   +1 more source

Strengthening Responses to Older Adult Abuse: A Review of Contextual Prevention Strategies in Australian Policy

Australian Journal of Social Issues, EarlyView.
ABSTRACT Older adult abuse is a significant social issue that has attracted necessary attention in Australian policy. Yet, the scope of abuse prevention strategies proposed within these policies has not been systematically reviewed, nor has their alignment with evidence‐informed frameworks been assessed.
Madeline Lee, Emily Moir, Nadine McKillop   +2 more
wiley   +1 more source

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

The endo-lysosomal-lipid axis: bidirectional interactions between membrane trafficking dysfunction and lipid metabolic disorders. [PDF]

Front Cell Dev Biol
Du Y, Li L, Du M, Xu Z, Zhang X, Cao W.
europepmc   +1 more source

Biallelic PIGB Variants Cause Motor Neuropathy with Conduction Blocks and Peripheral Nerve Hyperexcitability

Annals of Neurology, EarlyView.
Objective Glycosylphosphatidylinositol (GPI)‐anchored proteins play critical roles in nervous system function. Pathogenic variants in genes involved in GPI‐anchor biosynthesis cause early‐onset multisystem disorders known as inherited GPI deficiencies. We describe a novel neuromuscular phenotype associated with PIGB deficiency.
Gorka Fernández‐Eulate, Romain Duval, Marina Konyukh, Alessandro Bertini, Ayse Candayan, Albena Jordanova, Theresa Brunet, Wolfgang Müller‐Felber, Helena F. Pernice, Katrin Hahn, Nadja Ehmke, Juliane Beuschlein, Bertrand Isidor, Benjamin Cogné, Yann Péréon, Annabelle Chaussenot, John Rendu, Aysylu Murtazina, Dmitrii Subbotin, Artem Borovikov, Andrey Marakhonov, Chiara Pisciotta, Paola Saveri, Daniele Cazzato, Lucie Lemeray, Bérengère Koehl, Jean‐Madeleine de Sainte‐Agathe, Stefano Facchini, Ilaria Quartesan, Andrea Cortese, Yesim Parman, Arman Cakar, Davide Pareyson, Slim Azouzi, Tanya Stojkovic   +34 more
wiley   +1 more source

Integrating family-based interventions into specialty court programs: qualitative guidance from sex trafficking specialty court participants and their supportive family members. [PDF]

Health Justice
Murnan A, Mahon J, Jackson G, Pate S, Thompson S, Stewart C, Brown J, Manchak S, Butsch Kovacic M.   +8 more
europepmc   +1 more source

<i>Zea mays Drought-Overly Sensitive1/TUBA4</i> Is <i>Wilty3</i>, and Transcriptome Co-Expression Analysis of Shoot Meristem Mutant Tissues Reveals <i>Wilty2/TUB6:Wi3</i> Interactions Associated With Stem Vascular Bundle Development. [PDF]

Plant Direct
Dhingra A, Adhikari I, Rock CD.
europepmc   +1 more source

Out of Sight, Out of Mind: Shedding Light on Two Blind Spots in Harm Reduction Discourse. [PDF]

Drug Alcohol Rev
Clay S, Hall W.
europepmc   +1 more source