Results 61 to 70 of about 115,232 (254)

Does dose matter? Parental attendance in a preventive intervention for anxious and sad children

BMC Psychology
Background International studies show increasing prevalence of anxiety and depression among children. Parents are vital for children in all aspects of life, also in supporting their offspring in promoting better mental health, life skills and reducing ...
Elisabeth Valmyr Bania, Kristin Ytreland, Anne Mari Sund, Stian Lydersen, Simon Peter Neumer, Frode Adolfsen, Kristin Martinsen, Lene-Mari Potulski Rasmussen, Jo Magne Ingul   +8 more
doaj   +1 more source

Do frequency of visits with birth parents impact children’s mental health and parental stress in stable foster care settings

Cogent Psychology, 2018
This article explores whether the number of visits by birth parents influence perceptions of attachment, children’s competence and mental health, and stress levels in foster parents.
Sturla Fossum, Svein Arild Vis, Amy Holtan   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Does the Incredible Years Teacher Classroom Management Training programme have positive effects for young children exhibiting severe externalizing problems in school?: a quasi-experimental pre-post study

BMC Psychiatry, 2016
Background Young children exhibiting severe externalizing problems in school are at risk of developing several poor outcomes. School-based intervention programs have been found to be effective for students with different problems, including those with ...
Bente Kirkhaug, May Britt Drugli, Bjørn Helge Handegård, Stian Lydersen, Merethe Åsheim, Sturla Fossum   +5 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Developing a prognostic model for predicting preterm birth using a machine learning algorithm

BMC Pregnancy and Childbirth
Background Accurate assessment of preterm birth (PTB) risk allows for early symptom management to prolong gestation or prevent PTB, as well as enhanced perinatal survival and treatment outcomes.
Fatemeh Abdi, Nasibeh Roozbeh, Fatemeh Darsareh, Vahid Mehrnoush, Mohammad Sadegh Vahidi Farashah, Farideh Montazeri   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The power of machine learning models in predicting gestational diabetes mellitus

BMC Pregnancy and Childbirth
Background Gestational diabetes mellitus (GDM) is associated with various adverse outcomes in pregnancy for the mother and the baby. Precise prediction of GDM trends are crucial for public health.
Vahid Mehrnoush, Ali Haghighat, Anna Nami, Nazanin Rezaei, Fatemeh Darsareh, Farideh Montazeri, Mozhgan Saffari   +6 more
doaj   +1 more source

‘I Think It’s So Complicated Knowing What to Make of What Children Show’: On Child Welfare Employees’ Assessments of Children’s Reactions to Visitation

Social Sciences
The theme of this article is how child welfare workers understand children’s reactions when they assess visitation between parents and children in public care in Norway. The data material consists of 35 transcribed, anonymised recordings of child welfare
Tanja Røed Larsen
doaj   +1 more source