Results 121 to 130 of about 15,284,221 (342)

“The Brains Are Frozen”: Precarious Subjectivities in the Humanitarian Aid Sector in Jordan

Social Inclusion
Under the influence of neoliberal policies and marketisation dynamics, the humanitarian sector’s labour conditions become increasingly insecure. Based on one year of fieldwork in Amman, Jordan, and interviews with 39 aid professionals, this article ...
Brigit Ronde
doaj   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

The influence of work time adjustment on joint activities and the demand for child care [PDF]

In this paper we examine if partners in households coordinate their working times. Also we examine how this coordination influences the (in)formal demand for child care and the time spent on joint activities.
Maassen van den Brink, Henriette, Van Klaveren, Chris, Van Praag, Bernard   +2 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Frontline Experiences of Newly Arrived Refugees in Norway and Denmark

Nordisk Välfärdsforskning
The article examines the experiences of Syrian and Ukrainian refugees in their encounters with municipal integration workers in Norway and Denmark.
Karen N. Breidahl, Anne Britt Djuve, Hanne C. Kavli, Christian Albrekt Larsen, Rasmus Sandy Harboesgaard Nielsen   +4 more
doaj   +1 more source

Aboriginal Child Welfare [PDF]

, 2003
As the relationships between Canada’s Aboriginal peoples and the state undergo changes, the issue of Child Welfare is in the foreground; for it is around the well being, education and care of Aboriginal children that much of the painful historical ...
Blackstock, Cindy, Carlson, J. Clouston, Fine, Marshall, Mandell, Deena   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Exploring perceptions of genetic risk and the transmission of substance use disorders

Addiction Science & Clinical Practice
Background Substance use disorders (SUDs) have been consistently shown to exhibit moderate intergenerational continuity (1–3). While much research has examined genetic and social influences on addiction, less attention has been paid to clients’ and lay ...
Amanda Keller, Emily A. Bosk, Alicia Mendez, Brett Greenfield, Carolynn Flynn, Gina Everett (DelJones), Fabrys Julien, MacKenzie Michael   +7 more
doaj   +1 more source

Single Mothers Working at Night: Standard Work, Child Care Subsidies, and Implications for Welfare Reform [PDF]

Using a data set from the post welfare reform environment (the 1999 National Survey of America's Families), this paper investigates the impact of child care subsidies on the standard work (i.e., work performed during the traditional work hours of 8 a.m ...
Erdal Tekin
core  

The Children’s Perspectives Protocol: A participatory approach to studying child work issues [PDF]

, 1998
This is the summary of a research protocol constructed as part of the Radda Barnen project "Children’s perspectives on their working lives", originally published in 1998.
Woodhead, Martin
core