Results 91 to 100 of about 419,413 (333)

Population pharmacokinetics of TBAJ‐587 and its main metabolites—Evaluation of different loading dose strategies and early dose selection

British Journal of Clinical Pharmacology, EarlyView.
Background and Aim The rise of drug‐resistant tuberculosis (TB) poses a need for new drugs and combinations. TBAJ‐587, a new diarylquinoline (DARQ), has shown promising efficacy in preclinical studies. This work aimed to describe the pharmacokinetics (PK) of TBAJ‐587 and its metabolites M2 and M3 after single ascending dosing in healthy volunteers and ...
Albin A. M. Leding, Paul Bruinenberg, Almari Conradie, Jerry Nedelman, Antonio Lombardi, Dean Hickman, Ulrika S. H. Simonsson   +6 more
wiley   +1 more source

Service evaluation of an early pregnancy loss support clinic in an inner London early pregnancy unit

BMC Health Services Research
Background Early pregnancy loss (EPL) can have profound implications for physical and psychological health. In the UK, significant variation in service provision exists for women affected by EPL.
Michelle Anderson, Gemma Gluckman, Tara Ajith, Emma Kirk, Maria Memtsa   +4 more
doaj   +1 more source

Perceptions of Adolescent Pregnancy Among Teenage Girls in Rakai, Uganda. [PDF]

, 2017
The leading causes of death and disability among Ugandan female adolescents aged 15 to 19 years are pregnancy complications, unsafe abortions, and childbirth.
Baumgartner, Joy Noel, Bonnevie, Erika, Ddaaki, William George, Maly, Christina, McClendon, Katherine A, Nakyanjo, Neema, Nalugoda, Fred Kakaire, Serwadda, David, Wagman, Jennifer A, Wawer, Maria J   +9 more
core   +2 more sources

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

PANDA e-health system as a tool to increase antenatal contacts and improve perinatal outcomes in Tanzania: adaptation and feasibility study

BMC Pregnancy and Childbirth
Background Antenatal attendance is critical for pregnant women to receive the screening, health education and care plans that can optimise positive perinatal outcomes.
Valentina Actis Danna, Paschal Mdoe, Salum Ally, Sifael Katengu, Giovanna Stancanelli, Shangwe Kibona, Rose Laisser, Tracey Mills, Happiness Shayo, Andrew Weeks, Tina Lavender   +10 more
doaj   +1 more source

Effectiveness of Community Based Safe Motherhood Promoters in Improving the Utilization of Obstetric care. The Case of Mtwara Rural District in Tanzania. [PDF]

, 2010
In Tanzania, maternal mortality ratio remains unacceptably high at 578/100,000 live births. Despite a high coverage of antenatal care (96%), only 44% of deliveries take place within the formal health services.
Declare Mushi, Rose Mpembeni, Albrecht Jahn, UNICEF, ICM/FIGO, UN, National Bureau of Statistics, SN Massawe, F Font, National Bureau of Statistics {Tanzania} & Macro International Inc. 1997, E Urassa, KM Moore, S Thaddeus, RS Ross, M Kowalewski, M Rosato, J Elder, A Kleinman, MotherCare Matters, E Murray, C Santarelli, WHO, SB Rifkin, T Lankester, B Nwakoby, JS Kiwanuka, United Nation., A Jahn, D Mushi, J Lennon, D Werner, Tanzania Ministry of Health, District Medical Officer, E Essien, U Lehmann, HB Kendah, BN Nwakoby, S Jessop, S Rowland, B Kunene, BC Mullany, District Medical Officer, G Walraven, M Thorogood   +43 more
core   +3 more sources

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Does Economic Uncertainty Affect the Decision to Bear Children? Evidence from East and West Germany [PDF]

, 2005
Although economic agents routinely face various types of economic uncertainty, their effects are often unclear and hard to assess, in part due to the absence of suitable measures of uncertainty.
Bhaumik, Sumon Kumar, Nugent, Jeffrey B.
core   +1 more source

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

Wound care and pressure ulceration in midwifery: a neglected area? [PDF]

, 2011
Wound care and pressure ulceration in midwifery are important and neglected areas within the profession where much work needs to be done, both clinically and educationally.
Deery, Ruth
core