Results 61 to 70 of about 499,244 (305)

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Eyes Wide Open: Spiritual Resources for Healing from Childhood Sexual Abuse [PDF]

, 1994
Reviewed Book: Cummings, Louise. Eyes Wide Open: Spiritual Resources for Healing from Childhood Sexual Abuse.
Ludwig, Susan
core   +1 more source

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

Serotonin transporter polymorphism (5HTTLPR), severe childhood abuse and depressive symptom trajectories in adulthood

BJPsych Open, 2015
Background Cross-sectional studies suggest that the serotonin transporter promoter region polymorphism (5-HTT gene-linked polymorphic region, 5HTTLPR) moderates the relationship between childhood abuse and ...
Timothy B. Nguyen, Jane M. Gunn, Maria Potiriadis, Ian P. Everall, Chad A. Bousman   +4 more
doaj   +1 more source

Results From the Long-Term Inmate Survey: Focus on Child Abuse Histories [PDF]

, 1998
This report of long-term inmates in Alaska correctional facilities attempts to describe the childhood experiences of a sample of long-term inmates, address the "cycle of abuse" issue; and present the correlates of abuse which may impact the pattern of ...
Barnes, Allan R., Curtis, Richard, Langworthy, Robert H.   +2 more
core  

Experiences of adults abused as children after discharge from inpatient treatment: Informal social support and self-care practices related to trauma recovery [PDF]

, 2005
This qualitative study explored adults’ perceptions of experiences that were helpful and unhelpful to their recovery from the traumatic effects of childhood physical and sexual abuse.
Gadbois, Susan, Harper, Kim, Palmer, Sally, Stalker, Carol   +3 more
core   +3 more sources

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Childhood Maltreatment and Amygdala-Mediated Anxiety and Posttraumatic Stress Following Adult Trauma

Biological Psychiatry Global Open Science
Background: Childhood abuse (physical, emotional, and sexual) is associated with aberrant connectivity of the amygdala, a key threat-processing region.
Farah Harb, Michael T. Liuzzi, Ashley A. Huggins, E. Kate Webb, Jacklynn M. Fitzgerald, Jessica L. Krukowski, Terri A. deRoon-Cassini, Christine L. Larson   +7 more
doaj   +1 more source

Associations between developmental timing of child abuse and conduct problem trajectories in a UK birth cohort

BMC Psychiatry, 2021
Background Although there is strong evidence for a relationship between child abuse and neglect and conduct problems, associations between child abuse experienced at different developmental stages and developmental trajectories of conduct problems have ...
Andreas Bauer, Gemma Hammerton, Abigail Fraser, Graeme Fairchild, Sarah L. Halligan   +4 more
doaj   +1 more source

Read-React-Respond: An integrative model for understanding sexual revictimization [PDF]

, 2011
Females who have been sexually abused in childhood are at significantly higher risk to be revictimized in adolescence and adulthood. Revictimization is associated with a raft of adverse mental and physical health outcomes, and so understanding why ...
Grych, John H., Noll, Jennie G
core   +2 more sources