Results 121 to 130 of about 12,891 (283)

Examination of the relationship between family climate and childhood traumas and internet addiction in university students

open access: yes, 2023
Bu araştırmanın amacı, üniversite öğrencilerinde aile iklimi, çocukluk çağı travmaları ve internet bağımlılığı arasındaki ilişkinin incelenmesidir. Bu çalışmanın örneklem grubunu çeşitli bölümlerde okuyan 494 öğrenci oluşturmaktadır.
Ova, Mesut
core  

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

open access: yesAdvanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang   +9 more
wiley   +1 more source

The Mediating Role of Alexithymia in the Relationship Between Childhood Traumas and Depression

open access: yes
2nd International Canadian Scientific Research Congress / Editors:.Dr. Firuz FEVZI, Dr. Mariam S. OLSSON -- IKSAD Publishing House -- ISBN: 978-625-367-918-7 -- 2024.This study aimed to examine the mediating role of alexithymia in the relationship ...
Bilge, Yusuf, Balaban, Gülşah
core  

Masculinity and Violence: Early childhood traumas which lead to violent behavior in young boys

open access: yes, 2018
The goal of this study was to explore early childhood traumas young boys experience that may lead to violent behavior. The research questions for this study focused on childhood traumas, specifically child maltreatment, exposure to violence and drugs in ...
Gamble, Jowaun
core  

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

open access: yesAdvanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh   +7 more
wiley   +1 more source

Personalized Network‐Guided Neuromodulation Enhances Human Working Memory

open access: yesAdvanced Science, EarlyView.
A personalized neuromodulation framework combining individualized functional brain network targeting with real‐time neural decoding is introduced. Using concurrent TMS–fMRI, participant‐specific stimulation targets and optimal frequencies are identified. Only optimal‐frequency stimulation improves working memory across sessions.
Ahsan Khan   +13 more
wiley   +1 more source

The Role of Childhood Traumas in Adult Hashimoto’s Thyroiditis Erişkin Hashimoto Tiroiditinde Çocukluk Çağı Travmalarının Rolü

open access: yes
Objective: Hashimoto’s thyroiditis (HT) is the most common autoimmune thyroid disease. There are studies suggesting that childhood traumas cause hypothalamic-pituitary-adrenal axis dysfunction in adulthood, which predisposes patients to autoimmune ...
Aydoğan, Uğur   +2 more
core   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

open access: yesAdvanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou   +21 more
wiley   +1 more source

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