Results 201 to 210 of about 619,029 (288)

Pain assessment in non-verbal children with neurocognitive impairment: a review on current tools, challenges, and clinical perspectives. [PDF]

Front Pain Res (Lausanne)
Shaban R.
europepmc   +1 more source

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

Advanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul, Aiyarin Kittilukkana, Luis C. C. Huarte, Hiram Castillo‐Michel, Murielle Salome, Stéphane Roudeau, Pauline Belzanne, Matthieu Sainlos, Noémie Pied, Monica Fernandez‐Monreal, Daniel Choquet, Richard Ortega, Asuncion Carmona   +12 more
wiley   +1 more source

Taking Action through Emotional Connections

WOW Stories, 2008
Kathryn Tompkins
doaj  

Current trends in art and design for paediatric wellness in built environments (2020-2025): a thematic review. [PDF]

Front Pediatr
Zairul M, Hafizah N.
europepmc   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, EarlyView.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

Understanding by Looking Below the Surface

WOW Stories, 2009
Kathryn Tompkins
doaj  

Electroencephalography during acute painful procedures in neonates: a scoping review. [PDF]

Pain Rep
Gunawan PY, Baxter L, Cobo MM, van der Vaart M, Iyer S, Monk V, Anand KJS, Berde CB, Coviello C, Daliri MR, Dumont G, Fellman V, Gholami B, Hartley C, Kuhn P, Maitre NL, Mansfield RC, Marchant S, Nilsson S, Norman E, Talebi S, Wang S, Allegaert K, Davis JM, Turner MA, Ward RM, Darsey E, Sheppard JP, Bhatt A, van den Anker J, Massaro AN, Singh K, Slater R.   +32 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Understanding Disease Aetiology and Related Needs Knowledge of Parents of Children With Spina Bifida. [PDF]

Child Care Health Dev
Clark OE, Suhs MC, Hilderbrand TL, Ridosh MM, Wartman EC, Darow E, Holmbeck GN.   +6 more
europepmc   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source