Results 111 to 120 of about 5,176,637 (292)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Exploring Children’s Rights through a Global Literacy Community in the Land of Enchantment

open access: yesWOW Stories, 2022
The members of the Global Literacy Community of the Land of Enchantment share stories of their journeys in this vignette as each member use global literature to discuss the theme of children's rights as a central focus to the literacy community. Children’
Diana Botello   +3 more
doaj  

The impact of the Ebola epidemics on children's rights: a scoping review. [PDF]

open access: yesGlob Health Action, 2022
Lunghi I   +8 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Children's Rights in Islamic Law: A Contemporary Study of Family Practices

open access: yesMetro Islamic Law Review
Children are creatures created by God that must be protected and maintained with honor and dignity. The fulfillment of children's rights is an interesting issue to discuss.
Siti Nurjanah   +4 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Exploring the Landscape of Children’s Rights in Sports: A Scoping Review of Research Topics and Approaches in Social Sciences

open access: yesYoung
The aim of this study was to contribute to the research field of children’s rights in sports by synthesizing the scientific approaches applied and topics addressed in previous social science research focused on children’s rights per se .
Georgios Pavlogiannis   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

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