Results 221 to 230 of about 7,028,389 (249)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

open access: yesAdvanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng   +16 more
wiley   +1 more source

The Classroom as Salon: A Collaborative Project on Daniel Defoe’s Robinson Crusoe

open access: yesDigital Defoe: Studies in Defoe & His Contemporaries, 2013
Suzan Alteri
doaj  

Priorities for improving paediatric diagnosis: findings from a modified Delphi study. [PDF]

open access: yesBMJ Qual Saf
Rasooly IR   +24 more
europepmc   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

open access: yesAdvanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae   +5 more
wiley   +1 more source

A Rapid Realist Review of Trauma-Responsive Approaches in Children’s Homes: The NEST Study

open access: yes
Ariss SMB   +10 more
europepmc   +1 more source

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