Results 91 to 100 of about 344,642 (309)

Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma

Advanced Science, EarlyView.
Lactylation, linked to glycolysis, is poorly understood in regulation. It is found that LDHA is lactylated at Lys81/Lys318 by AARS1, boosting its activity and cellular lactylation via positive feedback in LUAD. Lactylation regulates NHEJ‐related proteins; their delactylation impairs NHEJ and increases cisplatin sensitivity, offering anticancer insights.
Jizhuo Li, Wenze Xun, Xijie Wang, Ruiguang Luo, Qifan Hu, Zhaocai Zhou, Jian Yuan, Yanan Wang, Xiaorui Wan, Tao Zhao, Tianyu Han, Jian‐Bin Wang   +11 more
wiley   +1 more source

Información científica en diarios electrónicos hispanoamericanos: El caso del aterrizaje del 'Curiosity'

Index Comunicación, 2012
Las noticias del ámbito científico o tecnológico no suelen ocupar un espacio abundante en la prensa diaria. El descenso del vehículo explorador 'Curiosity' en Marte ha sido una de las oportunidades en que se podía esperar una cobertura de prensa ...
Raymond Colle, Pontificia Universidad Católica de Chile   +1 more
doaj  

Status of Atlantic halibut (Hippoglossus hippoglossus) aquaculture production technology in Chile

, 2021
Pablo Gallardo, Guilherme Wolff Bueno, Cristián Araneda, Tillmann J. Benfey   +3 more
openalex   +1 more source

Reprogramming Tumor‐Associated Macrophages via Targeted NAT10 Inhibition to Enhance Colorectal Cancer Immunotherapy

Advanced Science, EarlyView.
This study presents the sono‐sensitive nanorobot Sono@NAT10, which targets NAT10 condensates to reprogram tumor‐associated macrophages in colorectal cancer. By reducing the acetylation level of SRSF2 protein and activating HDAC10, Sono@NAT10 promotes M1 polarization, suppresses tumor progression, and strengthens immunotherapy. The approach demonstrates
Jiahao Zhu, Benjie Xu, Rui Hu, Bo Yang, Peipei Shen, Yu Xu, Xiaojun Zhang, Danqi Qian, Gang Wu, Shengjun Ji, Yutian Zhao, Ke Gu   +11 more
wiley   +1 more source

Attracting foreign R&D through international centres of excellence: early experiences from Chile [PDF]

, 2017
Laurens Klerkx, José Guimón
openalex   +1 more source

The impact of protected areas on poverty: evidence from Chile [PDF]

, 2022
Thaís Vilela, Alfonso Malky Harb, Carla Mendizábal Vergara   +2 more
openalex   +1 more source

Multiscale 3D Whole Joint Cellular and Molecular Mapping Reveals Disease‐Specific Neurovascular Plasticity Underlying the Structure‐Pain Relationship

Advanced Science, EarlyView.
This study presents MUSIC, a novel immunostaining and clearing method coupled with large‐field light sheet microscopy, enabling 3D high‐resolution cellular and molecular mapping of intact musculoskeletal joints across species and joint types. Using joint degenerative and injury models, disease‐specific neurovascular alterations are uncovered, revealing
Peng Chen, Jiaxin Chai, Abirami Soundararajan, R. Glenn Hepfer, Benjamin Kheyfets, Jiaxin Hu, Ishraq Alshanqiti, Swarnalakshmi Raman, Ikue Tosa, Jun Tae Huh, Matthew Yee, Brooke J. Damon, Shangping Wang, Yu Shin Kim, Man‐Kyo Chung, Mildred C. Embree, Janice S. Lee, Tong Ye, Hai Yao   +18 more
wiley   +1 more source

Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia

Advanced Science, EarlyView.
Acute myeloid leukemia (AML) remains a therapeutic challenge due to its heterogeneity and limited targets. Here, multi‐omics analyses are utilized, and it is revealed that AML cells, particularly the FLT3‐ITD+ subtype, undergo chaperone‐mediated ER stress, inducing surface translocation of ER chaperones.
Yimin Zhou, Zhenfei Zhong, Peng Hu, Weigang Wang, Ying Song, Na Yang, Fangyan He, Yajie Li, Qi Sa, Yanmei Yang, Qinmiao Sun, Tonghua Yang, Beibei Zhang, Dahua Chen   +13 more
wiley   +1 more source

Ultrathin, Unsinkable, Janus‐Faced Solar–Thermal Interfacial Evaporator for High‐Throughput Seawater Distillation and Solar‐Water Production

Advanced Science, EarlyView.
A nanostructured carbon‐coated porous polymeric scaffold is developed to accelerate the hydrological cycle, enabling solar–thermal freshwater production from saline water with reduced energy consumption and CO2 footprint. Abstract Solar–thermal distillation offers immense and hitherto untapped potential for energy‐efficient, sustainable freshwater ...
Mohammed Aslam Villan, Amrutha Suresh, Mukund Misra, Cintia Naranjo Ruiz, Neil R. Cameron, Sandip K. Saha, Subramaniam Chandramouli   +6 more
wiley   +1 more source

CONCEPCIÓN DE LA MUERTE EN EL JUDAÍSMO

Revista Cultura & Religión, 2008
El presente escrito, intentará presentar la concepción de la muerte en el judaísmo emanada de distintos textos fundamentales de la tradición judía. De allí que aparezcan en el mismo una serie decitas bíblicas, talmúdicas y una revisión de los ritos ...
Ana María Tapia, Estudios Judaicos, Universidad de Chile   +1 more
doaj