Results 101 to 110 of about 344,642 (309)
Advanced Science, EarlyView.This study identifies a smoking‐induced mechanism in LSCC whereby nicotine activates the CHRNA5–JAK2/STAT3 axis to drive STC2 transcription. STC2 upregulates TGFBI, which interacts with endothelial ITGA5 to regulate vascular permeability and promote metastasis.
Yujie Shen +5 more
wiley +1 more source
Coastal erosion in central Chile: A new hazard?
, 2017 Carolina Martı́nez +5 more
openalex +2 more sources
Advanced Science, EarlyView.This work introduces a beamforming‐based method to generate acoustic images from fiber‐optic distributed acoustic sensing (DAS) data. By performing 2D scanning around the sensing fiber, the approach enables near‐field imaging and localization of acoustic sources, even in regions distant from the fiber. A data‐driven DAS channel selection improves image
Marcelo A. Soto +1 more
wiley +1 more source
Solar energy resource assessment in Chile: Satellite estimation and ground station measurements
, 2014 Rodrigo Escobar +5 more
openalex +2 more sources
A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines
Advanced Science, EarlyView.OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin +4 more
wiley +1 more source
Multi-group confirmatory factor analysis of the life attitude profile in Chilean adolescents [PDF]
, 2021 Patricia Imbarack +2 more
openalex +1 more source
TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux
Advanced Science, EarlyView.TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang +14 more
wiley +1 more source
Advanced Science, EarlyView.Puerarin targets mitochondrial MIC19 in tumor‐infiltrating Tregs, impairing their immunosuppressive function and enhancing antitumor immunity. This study uncovers the metabolic dependency of tumor‐infiltrating Tregs and highlights a potential metabolic‐targeted immunotherapeutic strategy for liver cancer. Abstract Regulatory T cells (Tregs) are pivotal
Yu Li +10 more
wiley +1 more source