Results 131 to 140 of about 344,642 (309)

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

open access: yesAdvanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong   +22 more
wiley   +1 more source

The significance of U–Pb zircon ages in zoned plutons: the case of the Flamenco pluton, Coastal Range batholith, northern Chile

open access: hybrid, 2018
Natalia Rodríguez   +5 more
openalex   +1 more source

Stress‐Induced Melting Controlled Failure Mechanisms of Methane Hydrate

open access: yesAdvanced Science, EarlyView.
We study methane hydrate via nanoindentation and nuclear magnetic resonance (NMR), finding its regional melting and mechanical properties, challenging existing views on hydrogen‐bonded crystals. Abstract Methane hydrate, a kind of nonstoichiometric crystalline, attracted worldwide attentions as a promising substitute energy. Its Dissociation is thought
Yanlong Li   +9 more
wiley   +1 more source

50 años de memorias y geografías

open access: yesTrenzar
El presente dossier es un ejercicio de escritura colectiva que comparte una valiosa dosis de las emociones vividas el pasado 04 de septiembre del 2023.
Rodolfo Quiroz   +2 more
doaj  

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

open access: yesAdvanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang   +3 more
wiley   +1 more source

Developing a non-invasive algorithm for the diagnosis of steatotic liver disease in primary healthcare: a retrospective cohort study. [PDF]

open access: yesBMJ Health Care Inform
Spencer-Sandino M   +14 more
europepmc   +1 more source

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