Results 161 to 170 of about 1,811,893 (303)

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Multimodal physiotherapeutic management of postoperative complications in orthognathic surgery: A literature review and institutional protocol proposal. [PDF]

Med Oral Patol Oral Cir Bucal
Fernández-de-la-Reguera A, Muñoz A, Sotelo O, Toledo X.   +3 more
europepmc   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

The microendemic <i>Aegla expansa</i> (Aeglidae) survives in highly disturbed micro-basins of southern Chile. [PDF]

Zookeys
Muñoz-Pedreros A, Norambuena HV, Jara CG, Jara-Seguel P, Guerrero M, González-Urrutia M.   +5 more
europepmc   +1 more source

Evaluating the Chile Solidario program: results using the Chile Solidario panel and the administrative databases [PDF]

This paper presents the results of a three-year evaluation performed on the first cohorts of Chile Solidario, the most important anti-poverty program in Chile.
Andrés Hojman, Fernando Hoces de la Guardia, Osvaldo Larrañaga   +2 more
core  

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Teleneuropsychology in Latin America: Experiences and challenges during the COVID-19 pandemic. [PDF]

Dement Neuropsychol
Vera LO, Dechent C, Rodriguez MP, Crivelli L, Capuñay NSC, Brucki SMD, Okada-Oliveira M, Robert P, Quiroz YT, Antivilo-Bruna A, Ramirez AA, Lillo P, Carello MA, Torralva T, Ramos T, Duran-Aniotz C, Allegri R, Slachevsky A.   +17 more
europepmc   +1 more source

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source

Impact of a Volunteer-Delivered Spiritual Care Strategy on Preventing Post-Intensive Care Syndrome-Family in Relatives of Critically Ill ICU Patients: A Quasi-Experimental Study. [PDF]

Nurs Crit Care
Ruiz C, Alegria L, Olivares P, Rojas V, Taboada P, Manríquez D, Bakker J, Repetto P.   +7 more
europepmc   +1 more source

Rapid Steam‐Assisted Temperature Swing Adsorption for Direct Air Capture Using a Rotary Adsorber

Advanced Science, EarlyView.
This study presents a direct air capture (DAC) device based on a steam‐regeneration rotary adsorber for high‐purity CO2. Testing of the prototype demonstrates its capability for continuous and stable carbon capture with the potential to achieve ton‐scale.
Junye Wu, Yunhao Chen, Kuihua Wang, Yingjie Huo, Yanlin Chen, Quanwen Pan, Tianshu Ge   +6 more
wiley   +1 more source