Results 61 to 70 of about 344,642 (309)

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Identificación de áreas temáticas científicas mediante el análisis de co-palabras. El caso de la Universidad de La Frontera, Chile

Investigación Bibliotecológica: Archivonomía, Bibliotecología e Información, 2017
El artículo presenta una experiencia de análisis y gestión de información científica y tecnológica para la focalización de la Investigación, Desarrollo e Innovación (I+D+i) en la Universidad de La Frontera, Chile. El objetivo fue identificar y visualizar
Patricio Padilla, José Coloma, Jorge Petit Breuilh, Leonardo Mena, Daniel Barrios, Daniel Weinacker, Fabiola Vásquez, Blanca Villalobos, Cristian Alister, Ronald Cancino   +9 more
doaj   +1 more source

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

Advanced Science, EarlyView.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun, Miriayi Alimujiang, Wenfei Li, Shuqin Chen, Yingying Su, Tingting Hu, Xuhong Lu, Yafen Ye, Ningning Bai, Fan Hu, Xiaoya Li, Rongrong Xu, Jun Xu, Jiarui Zhao, Yan Lu, Xiaojing Ma, Ying Yang   +16 more
wiley   +1 more source

An analysis of temperature anomalies in Chile using fractional integration [PDF]

, 2023
Luis A. Gil‐Alana, Miguel Martin-Valmayor, Cristina Hube-Antoine   +2 more
openalex   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Hernán Vera Lamperein y su participación en el movimiento de renovacion gradual de la educación secundária en Chile - Hernan Vera Lamperein and his participation in the movement of gradual renewal of secondary education in Chile

História da Educação, 2014
Este trabalho tem como objetivos fundamentais destacar os principais traços biográficos de Hernán Vera Lamperein, Prêmio em Educação 2001, e descrever sua participação em uma das principais reformas educacionais que tomaram impulso no Chile entre 1945 e ...
Jaime Caiceo Escudero, Chile
doaj  

Las bandas de cataclasitas ordovícicas del Monzogranito Tambillo: manifestaciones de una subfase temprana de los movimientos oclóyicos en el Cordón de Lila, norte de Chile

Andean Geology, 2013
Se estudian las bandas de cataclastitas en el borde oriental del Plutón Tambillo. Se observan dos sistemas de bandas de cataclasis: uno noreste y el otro noroeste.
María José Palacios Herrera, Hans Niemeyer, Sebastien Meffre   +2 more
doaj   +1 more source

An HMM-DNN-Based System for the Detection and Classification of Low-Frequency Acoustic Signals from Baleen Whales, Earthquakes, and Air Guns off Chile [PDF]

, 2023
Susannah J. Buchan, Miguel Duran, Constanza Rojas, Jorge Wuth, Rodrigo Mahú, Kathleen M. Stafford, Néstor Becerra Yoma   +6 more
openalex   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

Advanced Science, EarlyView.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
wiley   +1 more source

Prevalence of OSA in chilean children and adolescents based on subscale of pediatric sleep questionnaire.

Journal of Oral Research, 2019
Objectives: We aimed to determine the prevalence of Obstructive Sleep Apnea (OSA) in children and adolescents from four districts of Santiago, Chile by using a six-question subscale from the Sleep-Related Breathing Disorders (SRBD) scale, which measures ...
Francisca Verdugo-Paiva, Catalina Würth, Sebastián Godoy, Pilar Santelices   +3 more
doaj   +1 more source