Results 81 to 90 of about 344,642 (309)

IV JORNADA DE INVESTIGACIÓN Y POLÍTICAS PÚBLICAS EN SALUD MENTAL

ARS Medica, 2019
El martes 8 de octubre de 2019 se realizó la IV Jornada de Investigación y Políticas Públicas en Salud Mental, organizada por el Departamento de Salud Mental del Ministerio de Salud en conjunto con el Departamento de Salud Pública de la Pontificia ...
Pontificia Universidad Católica de Chile
doaj  

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

High Proportion of Potential Candidates for Immunotherapy in a Chilean Cohort of Gastric Cancer Patients: Results of the FORCE1 Study [PDF]

, 2019
Miguel Córdova‐Delgado, Mauricio P. Pinto, Ignacio N. Retamal, Matías Muñoz‐Medel, María Loreto Bravo, María Florencia Fernández, Betzabé Cisternas, Sebastián Mondaca, César Sánchez, Héctor Galindo, Bruno Nervi, Carolina Ibáñez, Francisco Acevedo, Jorge Madrid, José Peña, Érica Koch, María J. Maturana, Diego Romero, Nathaly De La Jara, Javiera Torres, Manuel Espinoza, Carlos Balmaceda, Yuwei Liao, Zhiguang Li, Matías Freire, Valentina Gárate‐Calderón, Javier F. Cáceres, Gonzalo Sepúlveda-Hermosilla, Rodrigo Lizana, Liliana Ramos, Rocío Artigas, Enrique Norero, Fernando Crovari, Ricardo Armisén, Alejandro H. Corvalán, Gareth I. Owen, Marcelo Garrido   +36 more
openalex   +1 more source

A revision of the Chilean Brachyglutini – Part 7. Revision of Achilia Reitter, 1890: A. cosmoptera species group (Coleoptera: Staphylinidae: Pselaphinae) [PDF]

, 2021
Sergey A. Kurbatov, Giulio Cuccodoro, Giorgio Sabella   +2 more
openalex   +1 more source

A GLUTAMATE CYSTEINE LIGASE Gene StGSH1 Regulated by StERF10 Enhanced Glutathione Accumulation and Adaptation to Low Phosphorus Stress in Potato

Advanced Science, EarlyView.
The StERF10‐StGSH1 module coordinates glutathione (GSH) biosynthesis under low‐phosphorus stress. The low‐phosphate‐induced AP2/ERF transcription factor StERF10 directly activates the transcription of StGSH1 and enhances GSH accumulation. Consequently, GSH scavenges reactive oxygen species and provides sulfur for sulfolipid synthesis, facilitating the ...
Xiaocheng Tian, Mingjun Li, Xiaojia Huang, Markus Wirtz, Xiaohui Zheng, Shilong Fan, Jiang Tian, Shaoqun Liu, Zhonghua Liu, Hongbo Zhao   +9 more
wiley   +1 more source

Pseudomonas spp. Producing Antimicrobial Compounds Regulate Fungal Communities Inhabiting Wheat Crown in Southern Chile [PDF]

, 2022
H. Doussoulin, Noberto L. Arismendi, Ernesto A. Moya-Elizondo   +2 more
openalex   +1 more source

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, EarlyView.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

A Dynamic DNA Nano‐Antioxidant Targeting Galectin‐3 Attenuates Liver Fibrosis via Reducing Macrophage Oxidative Stress

Advanced Science, EarlyView.
This study developed a dynamic DNA nano‐antioxidant (DDN) for Galectin‐3 siRNA delivery, specifically targeting hepatic macrophages to suppress ROS‐driven fibrosis. DDN enhanced hepatic accumulation, restored NRF2 signaling, and attenuated oxidative stress, collagen deposition, and fibrotic progression in a CCl4‐induced cirrhosis model, demonstrating ...
Mengjia Peng, Jianguo Xu, Youjian Hong, Fei Fang, Yan Li, Duo Ci, Bowen Wang   +6 more
wiley   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Chilean Universities Under the Junta: Regime and Policy [PDF]

, 1986
Daniel Lévy
openalex   +1 more source