Results 41 to 50 of about 99,332 (263)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

A Real Time Evaluation of the Central Bank of Chile GDP Growth Forecasts. [PDF]

In this paper we evaluate the Central Bank of Chile annual GDP growth forecasts over the period 1991-2009 using a real-time database. We compare the Central Bank of Chile forecasts with those of the Survey of Professional Forecasters (SPF), Consensus ...
Pablo Pincheira
core  

Climate variability and forest fires in central and south‐central Chile

Ecosphere, 2018
AbstractThis paper evaluates the relationship between fire occurrence (number and burned area) and climate variability (precipitation and maximum temperatures) across central and south‐central Chile (32°–43° S) during recent decades (1976–2013). This region sustains the largest proportion of the Chilean population, contains ecologically important ...
Urrutia-Jalabert, Rocío, González, Mauro E., González-Reyes, Álvaro, Lara, Antonio, Garreaud Salazar, René   +4 more
openaire   +3 more sources

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Credibility and Inflation Targeting in Chile [PDF]

In this paper we present new evidence on the recent changes of the inflationary dynamics for the Chilean economy. We show that price rigidity has increased while the degree indexation based on past inflation has decreased over time. We also show that the
Luis F. Céspedes, Claudio Soto
core  

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

El pueblo marcha a la ofensiva : ...

, 2009
Representació d'un grup de persones amb banderes de Xile i de la Central Única de ...
Central Única de Trabajadores (Chile) (CUT)
core  

Hyperdroughts in central Chile: Drivers, Impacts and Projections

Hydrology and Earth System Sciences
Abstract. Owing to the Mediterranean-like and highly variable climate of western South America, moderate droughts (20–30 % precipitation deficit) recur every 3–5 years in central Chile, alternating with wet years. Since 2010, however, this region has experienced a continuous dry spell, including extremely dry conditions in 2019 and 2021, when annual ...
René Garreaud, Juan Pablo Boisier, Camila Alvarez-Garreton, Duncan A. Christie, Tomás Carrasco-Escaff, Iván Vergara, Roberto O. Chávez, Paulina Aldunce, Pablo Camus, Manuel Suazo-Álvarez, Mariano Masiokas, Gabriel Castro, Ariel Muñoz, Mauricio Zambrano-Bigiarini, Rodrigo Fuster, Lintsiee Godoy   +15 more
openaire   +2 more sources

Wave energy assessment in the central-south coast of Chile

Renewable Energy, 2017
Abstract This paper presents an assessment of the wave energy resource in nearshore waters along the central coast of Chile (Lat.:32.5° S to 42.5° S). The assessment is built upon the combined use of hindcast and measured data collected specifically for this goal.
Felipe Lucero, Patricio A. Catalán, Álvaro Ossandón, José Beyá, Andrés Puelma, Luis Zamorano   +5 more
openaire   +3 more sources