Results 91 to 100 of about 151,342 (295)

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Chili [PDF]

Revue de droit comparé du travail et de la sécurité sociale, 2017
  +8 more sources

Analyse critique du discours politique français de l’école inclusive [PDF]

Synergies Chili, 2018
L’objectif de ce travail est d’analyser et d’évaluer le discours politique actuel qui justifie la stratégie de l’éducation inclusive en France. La méthodologie utilisée est celle de l’analyse du discours politique de Fairclough et Fairclough (2012) qui ...
Perrine Delbury
doaj  

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Perbandingan Pendapatan Usahatani Cabai Rawit dengan Menggunakan Pupuk Anorganik dan Pupuk Campuran(Organik, dan Anorganik) (Studi Kasus di Subak Kudungan, Desa Bontihing, Kecamatan Kubutambahan, Kabupaten Buleleng) [PDF]

, 2017
The Comparison of Hot Chili Farming Incomes by Using Organic Fertilizer and Mixture Fertilizer (Organic, and Inorganic)(Case Study In Subak Kudungan, Bontihing Village, Kubutambahan Distric,Buleleng Regency)The problem faced by famers of hot Chili is ...
ARDIAN, R. (RIFKI), RANTAU, I. K. (I), SUDARTA, W. (WAYAN)   +2 more
core  

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Reflexiones sobre al arte creado por mujeres [PDF]

Synergies Chili, 2016
El artículo es una reflexión basada en evidencias respecto de los dualismos jerárquicos que se presentan en nuestra sociedad y cultura occidental. Se analizan dos dualismos cuyos polos son hombre-mujer y ciencia-arte.
E. Verónica Romo López
doaj  

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Paysage interculturel [PDF]

Synergies Chili, 2019
Les écoles publiques chiliennes font à présent, face au défi d’alphabétiser les élèves haïtiens en espagnol, enfants de parents parlant le créole et parfois, le français.Le premier contact pour aborder l’éducation de ces enfants est pris en charge par ...
Marina Palacios Parra
doaj  

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source