Results 101 to 110 of about 20,714 (300)

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Value chain analysis of Paprika and Bird's Eye Chillies in Malawi [PDF]

Total LandCare Malawi (TLC) is implementing a three-year USAID-funded Spice Promotion in Commercial Enterprises (SPICE) project in collaboration with NALI Limited and ASSNAP.
Chitika, Rollins, Makoka, Donald, Simtowe, Franklin   +2 more
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Negotiation tools for vegetable commodity chain in Vientiane : SUSPER (sustainable development of peri-urban agriculture in South-East Asia) project [PDF]

, 2003
This report gives an overview of the vegetable sector in Vientiane prefecture in terms of production and market (supply and demand). The report is based on secondary data (see bibliography) and some preliminary results from the analysis of the data ...
Le Coq, Jean-François
core  

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

Advanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul, Aiyarin Kittilukkana, Luis C. C. Huarte, Hiram Castillo‐Michel, Murielle Salome, Stéphane Roudeau, Pauline Belzanne, Matthieu Sainlos, Noémie Pied, Monica Fernandez‐Monreal, Daniel Choquet, Richard Ortega, Asuncion Carmona   +12 more
wiley   +1 more source

Adding Value To Under utilised Fish Species [PDF]

, 2006
End of project reportTightening fish quotas and supply shortages for conventional species are causing major difficulties for both fishermen and seafood processors. There is a need, therefore, to explore the potential of underutilised fish species both as
Fagan, John, Gormley, Ronan T., Mitchell, Michelle   +2 more
core  

An Economic Analysis of Production and Marketing of Chilli in Mokokchung District of Nagaland

Arthshastra : Indian Journal of Economics & Research, 2016
The present study was based on information collected from 50 chilli growers, 12 retailers, and eight wholesalers from the Mokokchung district of Nagaland in the crop year 2012-13 through a pre-tested well designed questionnaire. Purposively, the paper intended to discover the surplus, cost, margin, and price spread of chilli production and marketing in
, Sashimatsung, Giribabu M.
openaire   +2 more sources

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

System Comparisons between Organic, Biodynamic, Conventional and GMO’s in cotton production & Organic, Biodynamic, Conventional systems in Soya and Wheat in Central India [PDF]

, 2008
Over the past 05 years the organic cotton production in India has grown many folds. In the conventional cotton arena the genetically modified cotton is growing at an unprecedented rate.
Baruah, Rajeev
core