Results 101 to 110 of about 2,466 (259)

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Soil physico-chemical properties and microbial diversity on chilli anthracnose disease severity in Northern Karnataka, India

Sains Tanah: Journal of Soil Science and Agroclimatology
Chilli anthracnose disease causes a huge commercial loss in the globe. Studying soil physico-chemical properties is crucial to understand chilli anthracnose because these properties significantly affect the efficacy of biocontrol agents and herbicides ...
Simran Panigatti, Devarajan Thangadurai, Jeyabalan Sangeetha, Ravichandra Hospet, Govardhana Guggalada Yadav, Smita Shinde, Vijaykumar Narayanaswamy Kondenahalli, Prabhudeva Shantappa Ajjappalavara, Poojashree Nagappa Kummur, Umesh Madar, Jiaojiao Song, Kasem Soytong   +11 more
doaj   +1 more source

Solid Ethanol as a Renewable, Low‐Toxicity, Electron‐Beam Direct Write, and Biomedical Material

Advanced Science, EarlyView.
3D ice lithography (3DIL) enables the fabrication of intricate submicrometer objects using ethanol as a renewable starting material. This study combines process optimization, structural and material analysis, and biomedical applications, from cell culture scaffolds to the patterning of neurostimulation electrodes, demonstrating performance in both in ...
Bruno Perdigão, Bingdong Chang, Gwendoline A. E. Anand, Lechan Tao, Kayeon Kim, Anne Zebitz Eriksen, Malte Alexander Schönhoff, Guilherme Ferreira, Xiyuan Liu, Su Genelioglu, Joachim Lyngholm‐Kjærby, Neha Zahoor, Johan Ulrik Lind, Alice Bastos da Silva Fanta, Thomas Willum Hansen, Changsi Cai, Anpan Han   +16 more
wiley   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Marketing of Chilli Production & Marketing Efficiency of Chillies Growing Farmers in Kurnool District

IOSR Journal of Humanities and Social Science, 2014
Dr.B. Thirumalesh, B. Bhagyalak shmamma
openaire   +1 more source

An appraisal of Chilli production technology adopted by the farmers of Punjab

Indian Journal of Extension Education, 2022
null Sunidhi, Dharminder Singh, S K Jindal   +2 more
openaire   +1 more source

Chilli-YOLO: An Intelligent Maturity Detection Algorithm for Field-Grown Chilli Based on Improved YOLOv10

智慧农业
[Objective]In modern agriculture, the rapid and accurate detection of chillies at different maturity stages is a critical step for determining the optimal harvesting time and achieving intelligent sorting of field-grown chillies. However, existing target
SI Chaoguo, LIU Mengchen, WU Huarui, MIAO Yisheng, ZHAO Chunjiang   +4 more
doaj   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source