This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Free Speech at Work: Verbal Harassment as Discriminatory (Mis)treatment [PDF]
In his reply to my article on workplace harassment law and freedom of speech, Professor Volokh does not respond to my most important critiques of his earlier work.
Epstein, Deborah
core +2 more sources
Apple Cultivation in Nontraditional Areas: Novel Perspectives and Advances A review
Low-chilling apple genotypes have become a viable alternative for cultivation in regions with moderate to mild winters due to concerns about the impact of global climate change.
Thakur Praveen +3 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Influence of climate change on the flowering of temperate fruit trees [PDF]
It is well known that winter chilling is necessary for the flowering of temperate trees. The chilling requirement is a criterion for choosing a species or variety at a given location.
Centeno Muñoz, Ana +5 more
core
Chilling Requirement of Ten Peach Cultivars Estimated by Different Models [PDF]
ABSTRACT.The adaptation of a temperate climate fruit cultivar to a certain area depends mainly on its chilling requirement and the chilling accumulation in such places. Several attempts have been made to estimate these two conditions, using different models.
MILECH, C. G. +5 more
openaire +2 more sources
Research on Chilling Requirements and Physiological Mechanisms of Prunus mume
Low temperature plays a vital role in the growth and development of woody plants. In this research, based on the ability of artificial low temperatures to break dormancy, the Utah model was used to determine the chilling requirements (CR) of four early flowering Prunus mume Sieb. et Zucc.
Yuhan Zhang, Kaifeng Ma, Qingwei Li
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
A Picture Is Worth a Thousand Material-Connection Disclosures: Endorsers, Instagram, and the Federal Trade Commission’s Endorsement Guides [PDF]
With the spread of social-media advertising, the Federal Trade Commission (FTC) has made many attempts to regulate the burgeoning field. However, the complexity of social media makes it difficult to regulate without violating the First Amendment.
Myers, Lauren
core +1 more source
Extrato de alho melhora a superação da dormência de videiras ‘Niagara Rosada’em regiões subtropicais. [PDF]
Nas regiões com invernos amenos, normalmente as exigências de frio para a quebra de dormência de gemas de videiras não são atendidas, e apenas os produtos altamente tóxicos CaCN2 e H2CN2 são recomendados na viticultura convencional para quebra de ...
Botelho, Renato Vasconcelos +4 more
core +2 more sources

