Results 91 to 100 of about 10,407 (325)

Active Learning‐Accelerated Discovery of Fibrous Hydrogels with Tissue‐Mimetic Viscoelasticity

Advanced Functional Materials, EarlyView.
Active learning accelerates the design of fibrous hydrogels that mimic the viscoelasticity of native tissues. By integrating multi‐objective optimization and closed‐loop experimentation, this approach efficiently identifies optimal formulations from thousands of possibilities and decouples elasticity and viscosity. The resulting hydrogels offer tunable
Zhengkun Chen, Zheyuan Miao, Gary Tom, Austin H. Cheng, Elizaveta Gusarova, Benjamen Zondag, Tianyi Wu, Dianoosh Kalhori, Boris Hinz, Milad Abolhasani, Alán Aspuru‐Guzik, Eugenia Kumacheva   +11 more
wiley   +1 more source

Lessons from mouse chimaera experiments with a reiterated transgene marker:revised marker criteria and a review of chimaera markers [PDF]

, 2015
Recent reports of a new generation of ubiquitous transgenic chimaera markers prompted us to consider the criteria used to evaluate new chimaera markers and develop more objective assessment methods.
Guan-Yi Shen, Antonio Notarnicola-Harwood, Birtley, James R, James R. Birtley, Margaret A. Keighren, Flockhart, Jean, Jean Flockhart, Benjamin A. Hodson, John D. West, Notarnicola-Harwood, Antonio, Shen, Guan-Yi, Keighren, Margaret A, Hodson, Benjamin A, West, John D   +13 more
core   +1 more source

Transmission of Mycobacterium chimaera from Heater–Cooler Units during Cardiac Surgery despite an Ultraclean Air Ventilation System

Emerging Infectious Diseases, 2016
Heater–cooler units (HCUs) were recently identified as a source of Mycobacterium chimaera causing surgical site infections. We investigated transmission of this bacterium from HCUs to the surgical field by using a thermic anemometer and particle counter,
Rami Sommerstein, Christian Rüegg, Philipp Kohler, Guido V. Bloemberg, Stefan P. Kuster, Hugo Sax   +5 more
doaj   +1 more source

Mycobacterium chimaera infection following cardiac surgery in the United Kingdom: clinical features and outcome of the first 30 cases.

Clinical Microbiology and Infection, 2018
OBJECTIVES Mycobacterium chimaera infection following cardiac surgery, due to contaminated cardiopulmonary bypass heater-cooler units, has been reported worldwide. However, the spectrum of clinical disease remains poorly understood.
J. Scriven, A. Scobie, N. Verlander, A. Houston, T. Collyns, V. Cajic, O. Kon, T. Mitchell, O. Rahama, A. Robinson, S. Withama, P. Wilson, D. Maxwell, D. Agranoff, E. Davies, M. Llewelyn, S. Soo, A. Sahota, M. A. Cooper, M. Hunter, J. Tomlins, Simon Tiberi, S. Kendall, M. Dedicoat, E. Alexander, T. Fenech, M. Zambon, T. Lamagni, E. G. Smith, M. Chand   +29 more
semanticscholar   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Survival of glucose phosphate isomerase null somatic cells and germ cells in adult mouse chimaeras

Biology Open, 2016
The mouse Gpi1 gene encodes the glycolytic enzyme glucose phosphate isomerase. Homozygous Gpi1−/− null mouse embryos die but a previous study showed that some homozygous Gpi1−/− null cells survived when combined with wild-type cells in fetal chimaeras ...
Margaret A. Keighren, Jean H. Flockhart, John D. West   +2 more
doaj   +1 more source

The human splenic microcirculation is entirely open as shown by 3D models in virtual reality

Scientific Reports, 2022
The human spleen is equipped with an organ-specific microcirculation. The initial part of the venous circulation is formed by spleen-specific large microvessels, the sinuses. Sinuses eventually fuse to form venules and veins.
Birte S. Steiniger, Henriette Pfeffer, Simone Gaffling, Oleg Lobachev   +3 more
doaj   +1 more source

Mycobacterium Chimaera Mimicking Sarcoidosis [PDF]

Methodist DeBakey Cardiovascular Journal, 2018
Mycobacterium chimaera (M. chimaera) is a slow-growing nontuberculous mycobacteria usually associated with pulmonary infection in immunocompromised patients. Attributed to a specific brand of contaminated heater-cooler units used during cardiac surgery, M.
Sarju, Ganatra, Ajay, Sharma, Richard, D'Agostino, Thomas, Gage, Paula, Kinnunen   +4 more
openaire   +2 more sources

Engineering of Glioblastoma‐Derived Biomimetic Vesicles and Their Structural and Molecular Features

Advanced Healthcare Materials, EarlyView.
ABSTRACT Biomimetic nanosystems and vesicles have arisen as a novel approach to design vesicular transport systems with diverse therapeutic potential. The ‘biomimetic’ strategy involves the integration of cell membrane components into lipid bilayers, conferring them with biological properties originating from the cell of origin. Until now, most studies
Noelia Hernández‐Lobato, Hanan Abumanhal‐Masarweh, Martí de Cabo, Pablo Guerra, Marilena Hadjidemetriou, Neus Lozano, Kostas Kostarelos   +6 more
wiley   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source