Results 101 to 110 of about 112,352 (251)

Evolutionary Kuramoto dynamics unravels origins of chimera states in neural populations. [PDF]

PLoS Comput Biol
Zdyrski T, Pauls S, Fu F.
europepmc   +1 more source

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source

V-CHIMERA: An Immune-Inspired Verified Framework for Organizational Cyber Crisis Response Under Misinformation. [PDF]

Biomimetics (Basel)
Alghamdi F, Alqithami S.
europepmc   +1 more source

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Doc and the chimera conspiracy

, 2015
Doc and the Chimera Conspiracy, is a story that takes place in a world which diverged from our own in 1861 and led to a cooperation between the stoic science of Europe and the holistic science of indigenous people around the world.
Beltran, Jesus, II
core  

Novel cardiac abnormalities observed in CAH patients with tenascin-X haploinsufficiency. [PDF]

Front Endocrinol (Lausanne)
Sappl A, Sriramachandran AM, Lottspeich C, Vill K, Morak M, Welp AC, Dervishi O, Bidlingmaier M, Kunz S, Reisch N.   +9 more
europepmc   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

A pangenome-based strategy for designing a multi-epitope vaccine against non-toxin antigens of necrotic enteritis-associated Clostridium perfringens. [PDF]

Braz J Microbiol
Greco JPG, Gonçalves CN, Conceição FR, Kremer FS, da Silva Pinto L.   +4 more
europepmc   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Filtering of artificial chimeric reads generated by ligation preparation method of nanopore sequencing. [PDF]

iScience
Xie Z, Zhang J, Yang T, Bo X, Fu Z, Yang F, Ye F, Ni M.   +7 more
europepmc   +1 more source