Results 171 to 180 of about 191,343 (255)

Hippocampal phase precession may be generated by chimera dynamics. [PDF]

Front Neural Circuits
Masoliver M, Davidsen J, Nicola W.
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

A Lactoferricin B/Buforin Chimeric Peptide Causes a Rapid, Selective, Prolonged Cytotoxic Effect and Induces Apoptosis in HPV18-Positive Cervical Cancer Cells. [PDF]

ACS Omega
Ardila-Chantré N, Barragán-Cárdenas AC, Reyes-Calderón JE, Franco-Zambrano DS, Matta-Orjuela EA, Rivera-Monroy JE, Muñoz-Sáez E, Carabaña-García C, Parra-Giraldo CM, Fierro-Medina R, Rivera-Monroy ZJ, García-Castañeda JE.   +11 more
europepmc   +1 more source

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

African pygmy mouse iPSCs as a model for in vitro embryogenesis, interspecies chimerism, and blastocyst complementation. [PDF]

Cell Rep Methods
Gjonlleshaj P, Lenardič A, Tarnowska-Sengül M, Taborsky D, Trautmann CL, Agostinho de Sousa J, Bundschuh N, Veyrunes F, Sendoel A, Bar-Nur O.   +9 more
europepmc   +1 more source

Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits

Advanced Science, EarlyView.
A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu, Mei Yuan, Li‐Juan Tang, Fenglin Wang, Xia Chu, Jian‐Hui Jiang   +5 more
wiley   +1 more source

Polydopamine‐Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu, Mei Liu, Changxing Gao, Cheng Zhao, Feijie Zhao, Shuqing Dong, Bo Zhang, Qianmei Liu, Wenqian Zhang, Ming Zhao, Qianjin Lu   +10 more
wiley   +1 more source

Chimera: a block-based neural architecture search framework for event-based object detection. [PDF]

Front Artif Intell
Silva DA, Elsheikh A, Smagulova K, Fouda ME, Eltawil AM.   +4 more
europepmc   +1 more source

Extreme Kinetic Stability and RNase Resistance of Human Telomerase RNA G‐Quadruplexes Overcome by DHX36 Helicase

Advanced Science, EarlyView.
The RNA G‐quadruplexes formed at the 5'‐end of the RNA component of human telomerase possess extreme slow unfolding rate, rendering them resistant to nuclease degradation. The helicase DHX36 overcame this kinetic barrier and significantly reduced the folded fraction.
Qun Luo, Yashuo Zhang, Yingxian Qian, Huiying Zhan, Wenqiang Wu, Huijuan You   +5 more
wiley   +1 more source

A modular, single-protein envelope for targeted gene delivery. [PDF]

Mol Ther Oncol
Ding X.
europepmc   +1 more source