Results 191 to 200 of about 191,343 (255)

Investigating Phase Separation in Genome Folding via Multiscale Computational Modeling

Advanced Science, EarlyView.
Phase separation is emerging as a multiscale organizing principle of genome folding across scales, from nucleosomes and transcriptional condensates to chromatin domains and nuclear compartments. By integrating physics‐based simulations with data‐driven inference, computational modeling now links molecular interactions to nuclear architecture and points
Jiahu Tang, Cibo Feng, Haibin Su, Xiakun Chu   +3 more
wiley   +1 more source

Effects of Swapping 5HT3 and α7 Residues in Chimeric Receptor Proteins on RIC3 and NACHO Chaperone Actions. [PDF]

Molecules
Yan Z, Oruganti S, Iyer SK, Agarwal K, Gupta M, Adhikari K, Vijayan N, Doda J, Jain V, Lokhande AN, Nair AP, Nallanichakravarthula VSK, Weltzin MM, Loring RH.   +13 more
europepmc   +1 more source

TopCas: Topology‐Gated Cas12a via DNA‐RNA Chimeric Circular crRNA for Amplification‐Free Nucleic Acid Detection and Conditional Gene Editing

Advanced Science, EarlyView.
The TopCas platform utilizes an engineered DNA‐RNA chimeric circular crRNA to establish topology‐gated control over CRISPR‐Cas12a activity, enabling target‐triggered self‐catalytic amplification (preamplification‐free). This system seamlessly integrates highly sensitive molecular diagnostics with conditionally controlled gene editing, demonstrating ...
Shun Zhang, Wen Sun, Ting Xiao, Yali Wang, Xianlan Wu, Huiyou Chen, Ming Chen, Jun Zhang   +7 more
wiley   +1 more source

Chimera

, 2006
  +6 more sources

Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells. [PDF]

Sci Immunol
Saravia J, Chapman NM, Sun Y, Meng X, Risch I, Li W, Guy C, Shi H, Hu H, Dhungana Y, Li J, You Z, Kc A, Lim SA, Raynor JL, Shrestha S, Norton EG, La Grange SE, Robinson CG, Vogel P, Chi H.   +20 more
europepmc   +1 more source

Fundamental Challenges, Physical Implementations, and Integration Strategies for Ising Machines in Large‐Scale Optimization Tasks

Advanced Electronic Materials, EarlyView.
Ising machines are emerging as specialized hardware solvers for computationally hard optimization problems. This review examines five major platforms—digital CMOS, analog CMOS, emerging devices, coherent optics, and quantum systems—highlighting physics‐rooted advantages and shared bottlenecks in scalability and connectivity.
Hyunjun Lee, Joon Pyo Kim, Sanghyeon Kim
wiley   +1 more source

RNA-RNA interactome approaches provide in vivo evidence for a critical role of the Hfq rim face in sRNA-mRNA pairing. [PDF]

Nucleic Acids Res
Luo X, Zhang A, Esnault C, De Mets F, Adams PP, Dale RK, Storz G, Gottesman S.   +7 more
europepmc   +1 more source

AI Guided Protein Design for Next‐Generation Autogenic Engineered Living Materials

Advanced Intelligent Systems, EarlyView.
Autogenic engineered living materials (ELMs) integrate biology and materials science to create self‐regenerating and self‐healing materials. This perspective highlights emerging strategies in protein engineering and AI‐guided de novo design to expand the capabilities of autogenic ELMs.
Hoda M. Hammad, Anna M. Duraj‐Thatte
wiley   +1 more source

Integrating Artificial Intelligence With Droplet‐Based Microfluidics: Advances, Challenges, and Emerging Opportunities

Advanced Intelligent Systems, EarlyView.
Droplet‐based microfluidics enables precise, high‐throughput microscale reactions but continues to face challenges in scalability, reproducibility, and data complexity. This review examines how artificial intelligence enhances droplet generation, detection, sorting, and adaptive control and discusses emerging opportunities for clinical and industrial ...
Junyan Lai, Sukrit Gaira, Rongfeng Wang, Qingtian Zhang, Ming Li, Liao Wu, Diangeng Li, Yi Li, Chengchen Zhang, Jinhong Guo, Shi‐Yang Tang   +10 more
wiley   +1 more source

CLDN5 as a novel modulator of podocyte adhesion to extracellular matrix via β1-integrin binding. [PDF]

J Biol Chem
Wang C, Han J, Fan B, Shen Y, An Y, Kong F, Ge N, Zhang X, Liu H, Wang M, Sun H, Zhou C, Zhao S, Gong Y.   +13 more
europepmc   +1 more source