Results 31 to 40 of about 112,352 (251)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos +9 more
wiley +1 more source
Chimera: Enabling Hierarchy Based Multi-Objective Optimization for Self-Driving Laboratories
, 2018 We introduce Chimera, a general purpose achievement scalarizing function (ASF) for multi-objective optimization problems in experiment design. Chimera combines concepts of a priori scalarizing with ideas from lexicographic approaches.
Alan Aspuru-Guzik +8 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi +5 more
wiley +1 more source
Rheumatologic Manifestations of Patients With Type B Insulin Resistance
Arthritis Care &Research, EarlyView.Objective The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...
S. Amara Ogbonnaya +4 more
wiley +1 more source
Active Learning‐Accelerated Discovery of Fibrous Hydrogels with Tissue‐Mimetic Viscoelasticity
Advanced Functional Materials, EarlyView.Active learning accelerates the design of fibrous hydrogels that mimic the viscoelasticity of native tissues. By integrating multi‐objective optimization and closed‐loop experimentation, this approach efficiently identifies optimal formulations from thousands of possibilities and decouples elasticity and viscosity. The resulting hydrogels offer tunable
Zhengkun Chen +11 more
wiley +1 more source
Integration of CFD tools in aerodynamic design of contra-rotating propellers blades [PDF]
, 2011 A strategy for Contra-Rotating Open Rotors blades design is presented. It is based on several analytical or CFD tools with increasing levels of accuracy. A preliminary design is made with a lifting-line code. These first geometries are then validated and
Béchet, Sylvain +3 more
core
Stability of spiral chimera states on a torus [PDF]
, 2017 We study destabilization mechanisms of spiral coherence-incoherence patterns known as spiral chimera states that form on a two-dimensional lattice of nonlocally coupled phase oscillators.
Oleh E. Omel'chenko +6 more
core +1 more source
Advanced Functional Materials, EarlyView.We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins +9 more
wiley +1 more source
Optimal design of tweezer control for chimera states
, 2018 Chimera states are complex spatio-temporal patterns which consist of coexisting domains of spatially coherent and incoherent dynamics in systems of coupled oscillators.
Oleh E. Omel'chenko +7 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino +12 more
wiley +1 more source