Results 221 to 230 of about 90,300 (269)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules. [PDF]

Elife
Cassell SJ, Li W, Krautwald S, Khoshouei M, Lee YT, Hou J, Guan W, Peukert S, Weihofen W, Whicher JR.   +9 more
europepmc   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Detection of PCR chimeras in adaptive immune receptor repertoire sequences. [PDF]

Bioinformatics
Chernyshev M, Stålmarck A, Corcoran M, Karlsson Hedestam GB, Murrell B.   +4 more
europepmc   +1 more source

Advances and perspectives in animal models of human hepatitis A virus

Animal Models and Experimental Medicine, EarlyView.
Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li, Pei‐Yu Jiang, Hui Zhao, Cheng‐Feng Qin   +3 more
wiley   +1 more source

Aminoacyl-tRNA Specificity of a Ligase Catalyzing Non-ribosomal Peptide Extension. [PDF]

J Am Chem Soc
Nguyen DT, Ramos-Figueroa JS, Vinogradov AA, Goto Y, Gadgil MG, Splain RA, Suga H, van der Donk WA, Mitchell DA.   +8 more
europepmc   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Engineering the ADDomer Nanoparticle Vaccine Scaffold for Improved Assembly and Enhanced Stability. [PDF]

ACS Synth Biol
Balchin G, Kabasakal BV, Strofaldi A, Hall S, Fletcher C, Buzas D, Bufton JC, Yadav SKN, Shen D, Garzoni F, Bunzel HA, McManus JJ, Schaffitzel C, Berger I.   +13 more
europepmc   +1 more source

A Machine Learning-Guided Approach for Identifying Potential HCAR1 Antagonists in Lactate-Driven Cancers. [PDF]

ACS Omega
Carvalho LV, Seyffert N, Meyer R, Tiwari S, Castro TLP.   +4 more
europepmc   +1 more source

Blocking axon-glial mechanotransduction to prevent concussive brain injury. [PDF]

Acta Neuropathol Commun
Sun C, Ma D, Hansen J, Tonniges JR, Hu H, Zhang L, Gu C.   +6 more
europepmc   +1 more source