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Risk-Adapted Donor Lymphocyte Infusion Based on Chimerism and Donor Source in Pediatric Leukemia [PDF]

open access: yesBlood Cancer Journal, 2013
Donor lymphocyte infusion (DLI) is commonly used to treat leukemia relapse following stem cell transplantation. In florid relapse, however, the efficacy of DLI is limited with substantial risk of severe graft-versus-host disease (GvHD).
Brandon M Triplett   +2 more
exaly   +2 more sources
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Chimeric xenotransplantation

Current Opinion in Organ Transplantation, 2019
Purpose of review Organ transplantation is an effective treatment for selected patients with end-stage organ disease or specific cancer types. Its main limitations are the chronic lack of grafts and the lifetime need for immunosuppression.
Oldani, Graziano   +2 more
openaire   +2 more sources

Chimeric Antibodies

2013
Here we describe a detailed protocol for the one-step preparation of antigen-specific human chimeric immunoglobulin G (IgG) monoclonal antibodies (mAbs) using an in vitro antibody design method referred to as the ADLib (Autonomously Diversifying Library) system.
Kohei, Kurosawa   +2 more
openaire   +2 more sources

Chimeric Proteins

2003
Most conventional vaccines consist of killed organisms or purified antigemc components of pathogens. However, this approach of vaccine development has several limitations. Large-scale growth of pathogens may be difficult to achieve and is not completely free of risk.
R, Janssen, J, Tommassen
openaire   +2 more sources

Chimerism of the Transplanted Heart

New England Journal of Medicine, 2002
Cases in which a male patient receives a heart from a female donor provide an unusual opportunity to test whether primitive cells translocate from the recipient to the graft and whether cells with the phenotypic characteristics of those of the recipient ultimately reside in the donor heart.
Quaini, F.   +8 more
openaire   +4 more sources

Chimerism in myositis

Current Rheumatology Reports, 2003
Bidirectional cell trafficking occurs between a mother and fetus during pregnancy. The trafficking is associated with the persistence of non-self cells. Persistence of these cells has been demonstrated after birth for many years in the child and mother.
openaire   +2 more sources

Human chimerism

Revue Francaise de Transfusion et Immuno-hématologie, 1981
After a short survey of the various kinds of human chimerism, 2 examples of spontaneous and permanent chimeras are presented: one case of blood chimerism in dizygotic male twins and a second case showing only one population of erythrocytes, lymphocytes and fibroblasts, in which the chimerism could only be detected by investigating the progeny of the ...
openaire   +2 more sources

The MPI Structure of Chimere

2012
The multiscale three dimensional Chemistry and Transport Model (CTM) package Chimere has been ported onto the segment of the European Grid Initiative platform available to the Virtual Organization COMPCHEM as part of the MPI parallelization activities of the European project EGI-Inspire.
LAGANA', Antonio   +3 more
openaire   +1 more source

Blood Chimeric Twins

Vox Sanguinis, 1977
Abstract. A man and his twin sister were found to have two types of circulating red cells. The man had 89% A1 cells of his own and 11% A1B cells derived from his sister. The woman had 12% A1B cells of her own and 88% A1 cells derived from her brother. The two lines of red cells also had different Duffy and Kidd groups.
T, Hosoi   +4 more
openaire   +2 more sources

Marrow Chimerism in Marmosets

Science, 1962
In the femoral marrow of three adult marmosets, two male Callithrix jacchus and one female Leontocebus rosalia , a number of opposite-sexed metaphases were found.
K, Benirschke   +2 more
openaire   +2 more sources

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