Results 101 to 110 of about 26,955 (234)
Exploring the Development of Vaccine Platforms, With a Particular Focus on the COVID‐19 Pandemic
Acta Paediatrica, EarlyView.ABSTRACT Vaccines have been a cornerstone of human health for more than 200 years and one of the most important tools to reduce childhood deaths caused by pathogens. The concept of vaccines is basically to take something safe, make it immunogenic and induce an immune response in the host that will protect it against something dangerous. Live attenuated
Matti Sällberg
wiley +1 more source
Lithic analysis in African archaeology: Advances and key themes
Archaeometry, EarlyView.Abstract Stone artifacts (lithics) preserve for extended periods; thus they are key evidence for probing the evolution of human technological behaviors. Africa boasts the oldest record of stone artifacts, spanning 3.3 Ma, rare instances of ethnographic stone tool‐making, and stone tool archives from diverse ecological settings, making it an anchor for ...
Deborah I. Olszewski +2 more
wiley +1 more source
Investigating relationships among strontium, barium, and seasonality in wild baboons
Archaeometry, EarlyView.Abstract Geochemical profiles of Australopithecus africanus and baboon teeth show fluctuating trace elements, possibly reflecting seasonal diets. Here we use laser ablation–inductively coupled plasma–mass spectrometric measurements of calcium‐normalized strontium and barium ratios (Sr/Ca and Ba/Ca) and ion microprobe analyses of oxygen isotopes (δ18O ...
Maya Bharatiya +12 more
wiley +1 more source
Trace Element Patterns in Juvenile Wild Chimpanzee Dentitions
Archaeometry, EarlyView.ABSTRACT Trace elements are used to infer mammalian early‐life diets, environmental toxins, dispersal patterns, stress histories, and weaning ages. Here, we employ laser ablation‐inductively coupled plasma‐mass spectrometry (LA‐ICP‐MS) to reveal elemental patterns in our closest living relatives, chimpanzees.
Tanya M. Smith +5 more
wiley +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Creativity and Innovation Management, EarlyView.ABSTRACT Artificial intelligence (AI) tools have become an integral part of organizational work, such as providing task‐relevant advice. Although existing research highlights the potential benefits of human‐AI collaboration for improving creative performance, recent findings question the universality of these effects.
Simon Berger, Julian Voigt
wiley +1 more source
Cancer Science, EarlyView.tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley +1 more source
Children &Society, EarlyView.ABSTRACT We situate this article from/with/in the Necrocene, a geological period marked by the systematic production of human and more‐than‐human death to an extent that ecological destruction, extinction, loss and harm have become a structural feature of modern life.
Charlotte Hankin, Hannah Hogarth
wiley +1 more source
Honouring Hardship and Fun: Reflecting on Homeless Children's Experiences in Shelter
Children &Society, EarlyView.ABSTRACT In our research with children living in a homeless shelter with their families in Southern Ontario, Canada, we navigated discrepancies between the challenges and hardships in our participants' lives and the fun, positive nature of many of our day‐to‐day interactions with them.
Rebecca Raby +4 more
wiley +1 more source