Results 91 to 100 of about 11,927,506 (403)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

COVID‐19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1953-1961, December 2022., 2022
Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic has had an unprecedented impact on the healthcare system, economy, and society. Studies have reported that COVID‐19 may cause various neurologic symptoms, including cognitive impairment.
Hanyu Zhang, Zengyuan Zhou
wiley   +1 more source

The Looming Threat of China: An Analysis of Chinese Influence on Bitcoin [PDF]

arXiv, 2018
As Bitcoin's popularity has grown over the decade since its creation, it has become an increasingly attractive target for adversaries of all kinds. One of the most powerful potential adversaries is the country of China, which has expressed adversarial positions regarding the cryptocurrency and demonstrated powerful capabilities to influence it. In this
arxiv  

The Impact of Industrial Zone:Evidence from China's National High-tech Zone Policy [PDF]

arXiv, 2023
Based on the statistical yearbook data and related patent data of 287 cities in China from 2000 to 2020, this study regards the policy of establishing the national high-tech zones as a quasi-natural experiment. Using this experiment, this study firstly estimated the treatment effect of the policy and checked the robustness of the estimation.
arxiv  

Law, Finance, and Economic Growth in China

, 2004
China is an important counterexample to the findings in the law, institutions, finance, and growth literature: Neither its legal nor financial system is well developed, yet it has one of the fastest growing economies.
Franklin Allen, Jun Qian, Meijun Qian
semanticscholar   +1 more source

Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study

British medical journal, 2020
Objective To assess the prevalence of diabetes and its risk factors. Design Population based, cross sectional study. Setting 31 provinces in mainland China with nationally representative cross sectional data from 2015 to 2017.
Yongze Li, D. Teng, Xiaoguang Shi, G. Qin, Yingfen Qin, Huibiao Quan, B. Shi, Hui Sun, J. Ba, Bing Chen, Jian-ling Du, Lanjie He, Xiaoyang Lai, Yanbo Li, H. Chi, Eryuan Liao, Chao Liu, Libin Liu, Xulei Tang, N. Tong, Guixia Wang, Jin-an Zhang, Youmin Wang, Yuan-ming Xue, Li Yan, Jing Yang, Lihui Yang, Yongli Yao, Z. Ye, Qiao Zhang, Lihui Zhang, Jun Zhu, Mei Zhu, G. Ning, Y. Mu, Jiajun Zhao, W. Teng, Z. Shan   +37 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Brain magnetic resonance imaging predictors in anti‐N‐methyl‐D‐aspartate receptor encephalitis

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1974-1984, December 2022., 2022
Abstract Objective Brain magnetic resonance imaging (MRI) findings in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis are nonspecific and rarely have obvious associations with clinical characteristics and outcomes. This study aimed to comprehensively describe the MRI features of patients with NMDAR encephalitis, examine their associations with ...
Ying‐Ying Zhao, Bing Han, Cui‐Hong Qin, Xue‐Xiu Shi, Wen‐Jing Yun, Meng Wang, Bo Yuan, Tong‐Wen Sun, Hai‐Xu Wang   +8 more
wiley   +1 more source

How can we bridge the gap between literacy and health in South Sudan?

South Sudan Medical Journal, 2019
Addressing the low literacy rates in South Sudan has been a longstanding priority for primary health care providers as a way to improve the country’s poor overall health status.
China Mayol Kuot
doaj  

We are extremely tired, with tremendous pressure,” A Follow-up Investigation of Foxconn [PDF]

, 2010
_We_are_extremely_tired__with_tremendous_pressure___A_Follow_up_Investigation_of_Foxconn_Electronics.pdf: 505 downloads, before Oct.
China Labor Watch
core   +1 more source