Results 101 to 110 of about 8,229,034 (354)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Brain magnetic resonance imaging predictors in anti‐N‐methyl‐D‐aspartate receptor encephalitis

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1974-1984, December 2022., 2022
Abstract Objective Brain magnetic resonance imaging (MRI) findings in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis are nonspecific and rarely have obvious associations with clinical characteristics and outcomes. This study aimed to comprehensively describe the MRI features of patients with NMDAR encephalitis, examine their associations with ...
Ying‐Ying Zhao, Bing Han, Cui‐Hong Qin, Xue‐Xiu Shi, Wen‐Jing Yun, Meng Wang, Bo Yuan, Tong‐Wen Sun, Hai‐Xu Wang   +8 more
wiley   +1 more source

Comparison of N uptake and internal use efficiency in two tobacco varieties

Crop Journal, 2015
To explain the observation in field experiments that tobacco variety CB-1 was more nitrogen (N)-efficient than K326, the influence of two N levels on growth, N uptake and N flow within plants of the two tobacco varieties was studied.
Department of Plant Nutrition, China Agricultural University, Beijing 100193, China, Wenqing Li , Chunjian Li    +2 more
doaj   +1 more source

The positive impact of lockdown in Wuhan on containing the COVID-19 outbreak in China

Journal of Travel Medicine, 2020
Background With its epicenter in Wuhan, China, the COVID-19 outbreak was declared a public health emergency of international concern (PHEIC) by the World Health Organization (WHO).
Hien Lau, Veria Khosrawipour, P. Kocbach, A. Mikołajczyk, Justyna Schubert, J. Bania, T. Khosrawipour   +6 more
semanticscholar   +1 more source

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

The anterior nucleus of the thalamus plays a role in the epileptic network

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2010-2024, December 2022., 2022
Abstract Objectives We investigated both the metabolic differences and interictal/ictal discharges of the anterior nucleus of the thalamus (ANT) in patients with epilepsy to clarify the relationship between the ANT and the epileptic network. Methods Nineteen patients with drug‐resistant epilepsy who underwent stereoelectroencephalography were studied ...
Hao Yan, Xueyuan Wang, Tao Yu, Duanyu Ni, Liang Qiao, Xiaohua Zhang, Cuiping Xu, Wei Shu, Yuping Wang, Liankun Ren   +9 more
wiley   +1 more source

China and India lead in greening of the world through land-use management

Nature Sustainability, 2019
Satellite data show increasing leaf area of vegetation due to direct factors (human land-use management) and indirect factors (such as climate change, CO2 fertilization, nitrogen deposition and recovery from natural disturbances).
Chi Chen, T. Park, Xuhui Wang, S. Piao, Baodong Xu, R. Chaturvedi, R. Fuchs, V. Brovkin, P. Ciais, R. Fensholt, H. Tømmervik, G. Bala, Zaichun Zhu, R. Nemani, R. Myneni   +14 more
semanticscholar   +1 more source

Effect of non-pharmaceutical interventions to contain COVID-19 in China

Nature, 2020
On 11 March 2020, the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a pandemic1. The strategies based on non-pharmaceutical interventions that were used to contain the outbreak in China appear to be effective2, but ...
S. Lai, N. Ruktanonchai, Liangcai Zhou, O. Prosper, W. Luo, J. Floyd, A. Wesolowski, M. Santillana, Chi Zhang, Xiangjun Du, Hongjie Yu, A. Tatem   +11 more
semanticscholar   +1 more source

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

FEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He, Guiyi Gong, Geovani Quijas, Simon Ming‐Yuen Lee, Ratan K. Chaudhuri, Krzysztof Bojanowski   +5 more
wiley   +1 more source

Comparative study of heat transfer from Nb-Ti and Nb_{3}Sn coils to He II

Physical Review Special Topics. Accelerators and Beams, 2008
In superconducting magnets, the energy deposited or generated in the coil must be evacuated to prevent temperature rise and consequent transition of the superconductor to the resistive state.
Marco La China, Davide Tommasini
doaj   +1 more source