Results 61 to 70 of about 8,992,180 (303)
Science China Life Sciences, 2020 Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease (COVID-19) and the evidence of person-to-person transmission. Limited data are available for asymptomatic infections. This study aims to present the
Zhiliang Hu +13 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Fracture and Structural Integrity, 2019 Stress corrosion slow strain rate tensile tests of the X80 steel in the natural seawater are carried out to study the effect of dissolved oxygen (DO) on the sensitivity of stress corrosion.
Zhong-ying Han +1 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
How can we bridge the gap between literacy and health in South Sudan?
South Sudan Medical Journal, 2019 Addressing the low literacy rates in South Sudan has been a longstanding priority for primary health care providers as a way to improve the country’s poor overall health status.
China Mayol Kuot
doaj
FEBS Open Bio, EarlyView.Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
wiley +1 more source
The first high-resolution meteorological forcing dataset for land process studies over China
Scientific Data, 2020 The China Meteorological Forcing Dataset (CMFD) is the first high spatial-temporal resolution gridded near-surface meteorological dataset developed specifically for studies of land surface processes in China. The dataset was made through fusion of remote
Jie He +6 more
semanticscholar +1 more source
Psychological status and behavior changes of the public during the COVID-19 epidemic in China [PDF]
, 2020 Xi Liu +7 more
openalex +1 more source