Results 171 to 180 of about 1,323,542 (252)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

open access: yesAdvanced Science, Volume 13, Issue 49, 3 September 2026.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong   +14 more
wiley   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

open access: yesAdvanced Science, Volume 13, Issue 49, 3 September 2026.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen   +12 more
wiley   +1 more source

Epiretinal Membrane Is Associated with Acquired Vitelliform Lesion Morphometrics in Intermediate Age-Related Macular Degeneration. [PDF]

open access: yesOphthalmol Sci
Quarta A   +13 more
europepmc   +1 more source

At the edge of change: Native Phragmites persistence and nonnative arrival along the dam‐regulated Colorado River

open access: yesAmerican Journal of Botany, Volume 113, Issue 9, September 2026.
Abstract Premise The southwestern United States is at the forefront of nonnative Phragmites australis subsp. australis expansion. Native Phragmites australis subsp. americanus, likely in decline in North America, is ecologically and culturally important and of conservation interest. In the greater Grand Canyon region, the Glen Canyon Dam led to loss of
Emily C. Palmquist   +6 more
wiley   +1 more source

Novel Diterpenoids From Salvia rosmarinus Reveal a Compound With Antiproliferative and Antioxidant Activities

open access: yesArchiv der Pharmazie, Volume 359, Issue 9, September 2026.
Four novel diterpenoids were isolated from Salvia rosmarinus (rosemary), together with nine known compounds. ECD calculations were employed to establish the absolute configuration of diterpenoids 1 and 2. The 18‐hydroxycarnosol (1) was evaluated as antiproliferative (SRB assay) and antioxidant (DPPH and TBARS), showing promising results.
Diana Pérez‐Juanchi   +5 more
wiley   +1 more source

Vacancy defect‐induced electron homing breaks phosphodiester bonds for RNA depletion‐driven cancer therapy

open access: yesBMEMat, Volume 4, Issue 3, September 2026.
Illustration of 5% S‐vacancy Bi2S3 mediated phosphodiester bonds cleavage in RNA of hepatocellular carcinoma cells, which suppressing ERI3 expression, inhibiting cell proliferation and promoting apoptosis. Abstract Genome‐wide hypertranscription is a hallmark of malignant progression.
Chuncheng Yang   +12 more
wiley   +1 more source

Lidocaine Combined With Platelet‐Rich Plasma for Stellate Ganglion Block in Chronic Migraine: A Multicenter, Prospective, Propensity Score‐Matched Cohort Study

open access: yesBrain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Objectives To explore the association of stellate ganglion block with platelet‐rich plasma plus lidocaine with clinical outcomes in adults with chronic migraine, in comparison to lidocaine alone. Methods This multicenter prospective exploratory study enrolled 200 adults with chronic migraine scheduled for stellate ganglion block across three ...
Lu Liu   +5 more
wiley   +1 more source

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